Abstract
This chapter provides an overview on lymphocytes and how they impact atherosclerosis initiation, progression, and aggravation. It examines how each major lymphocyte cell type contributes to or protects against atherosclerosis development, how this is accomplished, and any therapeutic potential these subsets possess. Specifically, the chapter discusses the role of traditional CD4+ T cell subsets including type 1 T-helper cells (Th1), type 2 T-helper cells (Th2), and natural killer T (NKT) cells. Then, it examines the contributions of emerging CD4+ T-cell subsets such as T regulatory cells (Tregs), T-helper 17 cells (Th17), and γδ T cells. Finally, the chapter explores how other lymphocyte cell types, such as B cells and NK cells, also participate in atherosclerosis. The continued improvement of our understanding of how these lymphocyte subsets participate in atherosclerotic pathogenesis could eventually lead to the development of novel therapeutics for atherosclerosis and atherosclerosis-related myocardial infarction and stroke.
Original language | English |
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Title of host publication | Atherosclerosis |
Subtitle of host publication | Risks, Mechanisms, and Therapies |
Publisher | Wiley-Blackwell |
Pages | 155-172 |
Number of pages | 18 |
ISBN (Electronic) | 9781118828533 |
ISBN (Print) | 9781118285916 |
DOIs | |
State | Published - Mar 27 2015 |
Externally published | Yes |
Keywords
- Atherosclerosis
- CD4+ T cell
- Lymphocytes
- Myocardial infarction
- Natural killer T (NKT)
- T regulatory cells (Tregs)
- T-helper 17 cells (Th17)
- Type 1 T-helper cells (Th1)
- Type 2 T-helper cells (Th2)
- γδ T cells