Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma

Danielle Shafer; Mitchell R. Smith; Hossein Borghaei; Michael M. Millenson; Tianyu Li; Samuel Litwin; Rachna Anad; Tahseen Al-Saleem

doi:10.1016/j.leukres.2013.07.038

Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma

Danielle Shafer, Mitchell R. Smith, Hossein Borghaei, Michael M. Millenson, Tianyu Li, Samuel Litwin, Rachna Anad, Tahseen Al-Saleem

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Host immune responses influence follicular lymphoma (FL) outcomes. To test our hypothesis that immune cells in blood reflect that response, we assessed by peripheral blood flow cytometry in 75 untreated FL patients the absolute counts of: lymphocytes (ALC), CD4⁺T (ACD4C), CD8⁺T (ACD8C) and natural killer (ANKC) cells. Low ANKC was the only parameter associated with inferior overall survival by univariate analysis (p=0.02), and trended to significance in multivariable analysis with ACD4C (p=0.08). Five (24%) patients with low initial ANKC died, while one (2%) with normal/high ANKC has died. In conclusion, evaluation of blood ANKC may be a useful indicator of outcome in previously untreated FL patients.

Original language	English
Pages (from-to)	1213-1215
Number of pages	3
Journal	Leukemia Research
Volume	37
Issue number	10
DOIs	https://doi.org/10.1016/j.leukres.2013.07.038
State	Published - Oct 2013

Keywords

Adult
Aged
Aged, 80 and over
Flow Cytometry
Follow-Up Studies
Humans
Killer Cells, Natural
Lymphocyte Count
Lymphoma, Follicular/blood
Middle Aged
Neoplasm Staging

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@article{27a1445e9a934e82b1d4ec6db3c9f7d2,

title = "Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma",

abstract = "Host immune responses influence follicular lymphoma (FL) outcomes. To test our hypothesis that immune cells in blood reflect that response, we assessed by peripheral blood flow cytometry in 75 untreated FL patients the absolute counts of: lymphocytes (ALC), CD4+T (ACD4C), CD8+T (ACD8C) and natural killer (ANKC) cells. Low ANKC was the only parameter associated with inferior overall survival by univariate analysis (p=0.02), and trended to significance in multivariable analysis with ACD4C (p=0.08). Five (24%) patients with low initial ANKC died, while one (2%) with normal/high ANKC has died. In conclusion, evaluation of blood ANKC may be a useful indicator of outcome in previously untreated FL patients.",

keywords = "Adult, Aged, Aged, 80 and over, Flow Cytometry, Follow-Up Studies, Humans, Killer Cells, Natural, Lymphocyte Count, Lymphoma, Follicular/blood, Middle Aged, Neoplasm Staging",

author = "Danielle Shafer and Smith, {Mitchell R.} and Hossein Borghaei and Millenson, {Michael M.} and Tianyu Li and Samuel Litwin and Rachna Anad and Tahseen Al-Saleem",

year = "2013",

month = oct,

doi = "10.1016/j.leukres.2013.07.038",

language = "English",

volume = "37",

pages = "1213--1215",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "10",

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TY - JOUR

T1 - Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma

AU - Shafer, Danielle

AU - Smith, Mitchell R.

AU - Borghaei, Hossein

AU - Millenson, Michael M.

AU - Li, Tianyu

AU - Litwin, Samuel

AU - Anad, Rachna

AU - Al-Saleem, Tahseen

PY - 2013/10

Y1 - 2013/10

N2 - Host immune responses influence follicular lymphoma (FL) outcomes. To test our hypothesis that immune cells in blood reflect that response, we assessed by peripheral blood flow cytometry in 75 untreated FL patients the absolute counts of: lymphocytes (ALC), CD4+T (ACD4C), CD8+T (ACD8C) and natural killer (ANKC) cells. Low ANKC was the only parameter associated with inferior overall survival by univariate analysis (p=0.02), and trended to significance in multivariable analysis with ACD4C (p=0.08). Five (24%) patients with low initial ANKC died, while one (2%) with normal/high ANKC has died. In conclusion, evaluation of blood ANKC may be a useful indicator of outcome in previously untreated FL patients.

AB - Host immune responses influence follicular lymphoma (FL) outcomes. To test our hypothesis that immune cells in blood reflect that response, we assessed by peripheral blood flow cytometry in 75 untreated FL patients the absolute counts of: lymphocytes (ALC), CD4+T (ACD4C), CD8+T (ACD8C) and natural killer (ANKC) cells. Low ANKC was the only parameter associated with inferior overall survival by univariate analysis (p=0.02), and trended to significance in multivariable analysis with ACD4C (p=0.08). Five (24%) patients with low initial ANKC died, while one (2%) with normal/high ANKC has died. In conclusion, evaluation of blood ANKC may be a useful indicator of outcome in previously untreated FL patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Flow Cytometry

KW - Follow-Up Studies

KW - Humans

KW - Killer Cells, Natural

KW - Lymphocyte Count

KW - Lymphoma, Follicular/blood

KW - Middle Aged

KW - Neoplasm Staging

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U2 - 10.1016/j.leukres.2013.07.038

DO - 10.1016/j.leukres.2013.07.038

M3 - Article

C2 - 23968916

SN - 0145-2126

VL - 37

SP - 1213

EP - 1215

JO - Leukemia Research

JF - Leukemia Research

IS - 10

ER -

Low NK cell counts in peripheral blood are associated with inferior overall survival in patients with follicular lymphoma

Abstract

Keywords

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