LOV conquers (sm)all GTPases

Rachelle Kosoff; Jonathan Chernoff

doi:10.3410/B2-28

LOV conquers (sm)all GTPases

Rachelle Kosoff, Jonathan Chernoff

Cancer Signaling and Microenvironment (CSM)

University of Pennsylvania

Research output: Contribution to journal › Short survey › peer-review

Abstract

Knowledge of spatial patterning of GTPases is critical to understanding protein function since subcellular localization is essential for normal protein function. In this paper, we discuss how Hahn's group has created a new type of genetically encoded, light-activated enzyme that allows precise temporal and spatial control of the small GTPase, Rac1. This reagent enables this group to analyze the roles of effector proteins in Rac1 function and may be applicable to other signaling proteins.

Original language	English
Article number	28
Journal	F1000 Biology Reports
Volume	2
Issue number	1
DOIs	https://doi.org/10.3410/B2-28
State	Published - Apr 12 2010

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LOV conquers (sm)all GTPases

Abstract

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