Lipidated peptidomimetics with improved antimicrobial activity

Yaogang Hu; Mohamad Nassir Amin; Shruti Padhee; Rongsheng E. Wang; Qiao Qiao; Ge Bai; Yaqong Li; Archana Mathew; Chuanhai Cao; Jianfeng Cai

doi:10.1021/ml3001215

Lipidated peptidomimetics with improved antimicrobial activity

Yaogang Hu, Mohamad Nassir Amin, Shruti Padhee, Rongsheng E. Wang, Qiao Qiao, Ge Bai, Yaqong Li, Archana Mathew, Chuanhai Cao, Jianfeng Cai

University of South Florida

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

Original language	English
Pages (from-to)	683-686
Number of pages	4
Journal	ACS Medicinal Chemistry Letters
Volume	3
Issue number	8
DOIs	https://doi.org/10.1021/ml3001215
State	Published - Aug 9 2012
Externally published	Yes

Keywords

antimicrobial peptides
drug resistance
lipidation
peptidomimetics
α-AApeptides

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10.1021/ml3001215

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title = "Lipidated peptidomimetics with improved antimicrobial activity",

abstract = "We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.",

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author = "Yaogang Hu and Amin, {Mohamad Nassir} and Shruti Padhee and Wang, {Rongsheng E.} and Qiao Qiao and Ge Bai and Yaqong Li and Archana Mathew and Chuanhai Cao and Jianfeng Cai",

year = "2012",

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doi = "10.1021/ml3001215",

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T1 - Lipidated peptidomimetics with improved antimicrobial activity

AU - Hu, Yaogang

AU - Amin, Mohamad Nassir

AU - Padhee, Shruti

AU - Wang, Rongsheng E.

AU - Qiao, Qiao

AU - Bai, Ge

AU - Li, Yaqong

AU - Mathew, Archana

AU - Cao, Chuanhai

AU - Cai, Jianfeng

PY - 2012/8/9

Y1 - 2012/8/9

N2 - We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

AB - We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

KW - antimicrobial peptides

KW - drug resistance

KW - lipidation

KW - peptidomimetics

KW - α-AApeptides

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DO - 10.1021/ml3001215

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SP - 683

EP - 686

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 8

ER -

Lipidated peptidomimetics with improved antimicrobial activity

Abstract

Keywords

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