Life in the inflamed intestine, Salmonella style

Renato L. Santos; Manuela Raffatellu; Charles L. Bevins; L. Garry Adams; Çagla Tükel; Renée M. Tsolis; Andreas J. Bäumler

doi:10.1016/j.tim.2009.08.008

Life in the inflamed intestine, Salmonella style

Renato L. Santos, Manuela Raffatellu, Charles L. Bevins, L. Garry Adams, Çagla Tükel, Renée M. Tsolis, Andreas J. Bäumler

Research output: Contribution to journal › Review article › peer-review

158 Scopus citations

Abstract

The lower gastrointestinal tract is densely populated with resident microbial communities (microbiota), which do not elicit overt host responses but rather provide benefit to the host, including niche protection from pathogens. However, introduction of bacteria into the underlying tissue evokes acute inflammation. Non-typhoidal Salmonella serotypes (NTS) elicit this stereotypic host response by actively penetrating the intestinal epithelium and surviving in tissue macrophages. Initial responses generated by bacterial host cell interaction are amplified in tissue through the interleukin (IL)-18/interferon-γ and IL-23/IL-17 axes, resulting in the activation of mucosal barrier functions against NTS dissemination. However, the pathogen is adapted to survive antimicrobial defenses encountered in the lumen of the inflamed intestine. This strategy enables NTS to exploit inflammation to outcompete the intestinal microbiota, and promotes the Salmonella transmission by the fecal/oral route.

Original language	English
Pages (from-to)	498-506
Number of pages	9
Journal	Trends in Microbiology
Volume	17
Issue number	11
DOIs	https://doi.org/10.1016/j.tim.2009.08.008
State	Published - Nov 2009

Access to Document

10.1016/j.tim.2009.08.008

Cite this

@article{e5d66a7526d34c338ea64577c784075d,

title = "Life in the inflamed intestine, Salmonella style",

abstract = "The lower gastrointestinal tract is densely populated with resident microbial communities (microbiota), which do not elicit overt host responses but rather provide benefit to the host, including niche protection from pathogens. However, introduction of bacteria into the underlying tissue evokes acute inflammation. Non-typhoidal Salmonella serotypes (NTS) elicit this stereotypic host response by actively penetrating the intestinal epithelium and surviving in tissue macrophages. Initial responses generated by bacterial host cell interaction are amplified in tissue through the interleukin (IL)-18/interferon-γ and IL-23/IL-17 axes, resulting in the activation of mucosal barrier functions against NTS dissemination. However, the pathogen is adapted to survive antimicrobial defenses encountered in the lumen of the inflamed intestine. This strategy enables NTS to exploit inflammation to outcompete the intestinal microbiota, and promotes the Salmonella transmission by the fecal/oral route.",

author = "Santos, {Renato L.} and Manuela Raffatellu and Bevins, {Charles L.} and Adams, {L. Garry} and {\c C}agla T{\"u}kel and Tsolis, {Ren{\'e}e M.} and B{\"a}umler, {Andreas J.}",

year = "2009",

month = nov,

doi = "10.1016/j.tim.2009.08.008",

language = "English",

volume = "17",

pages = "498--506",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd.",

number = "11",

}

TY - JOUR

T1 - Life in the inflamed intestine, Salmonella style

AU - Santos, Renato L.

AU - Raffatellu, Manuela

AU - Bevins, Charles L.

AU - Adams, L. Garry

AU - Tükel, Çagla

AU - Tsolis, Renée M.

AU - Bäumler, Andreas J.

PY - 2009/11

Y1 - 2009/11

N2 - The lower gastrointestinal tract is densely populated with resident microbial communities (microbiota), which do not elicit overt host responses but rather provide benefit to the host, including niche protection from pathogens. However, introduction of bacteria into the underlying tissue evokes acute inflammation. Non-typhoidal Salmonella serotypes (NTS) elicit this stereotypic host response by actively penetrating the intestinal epithelium and surviving in tissue macrophages. Initial responses generated by bacterial host cell interaction are amplified in tissue through the interleukin (IL)-18/interferon-γ and IL-23/IL-17 axes, resulting in the activation of mucosal barrier functions against NTS dissemination. However, the pathogen is adapted to survive antimicrobial defenses encountered in the lumen of the inflamed intestine. This strategy enables NTS to exploit inflammation to outcompete the intestinal microbiota, and promotes the Salmonella transmission by the fecal/oral route.

AB - The lower gastrointestinal tract is densely populated with resident microbial communities (microbiota), which do not elicit overt host responses but rather provide benefit to the host, including niche protection from pathogens. However, introduction of bacteria into the underlying tissue evokes acute inflammation. Non-typhoidal Salmonella serotypes (NTS) elicit this stereotypic host response by actively penetrating the intestinal epithelium and surviving in tissue macrophages. Initial responses generated by bacterial host cell interaction are amplified in tissue through the interleukin (IL)-18/interferon-γ and IL-23/IL-17 axes, resulting in the activation of mucosal barrier functions against NTS dissemination. However, the pathogen is adapted to survive antimicrobial defenses encountered in the lumen of the inflamed intestine. This strategy enables NTS to exploit inflammation to outcompete the intestinal microbiota, and promotes the Salmonella transmission by the fecal/oral route.

UR - http://www.scopus.com/inward/record.url?scp=70350340706&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2009.08.008

DO - 10.1016/j.tim.2009.08.008

M3 - Review article

C2 - 19819699

SN - 0966-842X

VL - 17

SP - 498

EP - 506

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 11

ER -

Life in the inflamed intestine, Salmonella style

Abstract

Access to Document

Other files and links

Fingerprint

Cite this