TY - GEN
T1 - Laser-induced breakdown spectroscopy of whole blood and other liquid organic compounds
AU - Melikechi, N.
AU - Ding, H.
AU - Rock, S.
AU - Marcano, A. O.
AU - Connolly, D.
PY - 2008
Y1 - 2008
N2 - We report on laser-induced breakdown spectroscopy (LIBS) of whole blood and other organic fluids. LIBS spectra, in the region 200-970 nm, are measured by recording the radiation emitted by the samples following their ablation in a helium environment. We show that these spectra, although very complex, reveal the presence of elements such as nitrogen, hydrogen, oxygen and carbon and that of important metallic elements such as iron, magnesium, calcium, potassium, and sodium. We compare the measured LIBS spectra of whole blood to that of pure carbon and pure iron and find that in the 200-300 nm region. Nearly 90% of the peaks can be assigned to only these two elements. We also report on similar studies of methanol, ethanol, isopropanol and water solutions of protein molecules of interest to cancer research. We show that using simple numerical algorithms, it is possible to distinguish between complex organic compounds that have nearly the same chemical composition.
AB - We report on laser-induced breakdown spectroscopy (LIBS) of whole blood and other organic fluids. LIBS spectra, in the region 200-970 nm, are measured by recording the radiation emitted by the samples following their ablation in a helium environment. We show that these spectra, although very complex, reveal the presence of elements such as nitrogen, hydrogen, oxygen and carbon and that of important metallic elements such as iron, magnesium, calcium, potassium, and sodium. We compare the measured LIBS spectra of whole blood to that of pure carbon and pure iron and find that in the 200-300 nm region. Nearly 90% of the peaks can be assigned to only these two elements. We also report on similar studies of methanol, ethanol, isopropanol and water solutions of protein molecules of interest to cancer research. We show that using simple numerical algorithms, it is possible to distinguish between complex organic compounds that have nearly the same chemical composition.
KW - Laser ablation of liquid samples
KW - Laser-induced breakdown spectroscopy of biosamples
KW - Whole blood analysis
UR - http://www.scopus.com/inward/record.url?scp=45149087636&partnerID=8YFLogxK
U2 - 10.1117/12.761901
DO - 10.1117/12.761901
M3 - Conference contribution
AN - SCOPUS:45149087636
SN - 9780819470386
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Diagnostics and Sensing VIII
T2 - Optical Diagnostics and Sensing VIII
Y2 - 21 January 2008 through 23 January 2008
ER -
