Langerhans cell histiocytosis of the uvea with neovascular glaucoma: Diagnosis by fine-needle aspiration biopsy and management with intraocular bevacizumab and brachytherapy

Carol L. Shields; Michael D. Hogarty; Brad E. Kligman; Colleen Christian; Hormoz Ehya; Jerry A. Shields

doi:10.1016/j.jaapos.2010.10.007

Langerhans cell histiocytosis of the uvea with neovascular glaucoma: Diagnosis by fine-needle aspiration biopsy and management with intraocular bevacizumab and brachytherapy

Carol L. Shields, Michael D. Hogarty, Brad E. Kligman, Colleen Christian, Hormoz Ehya, Jerry A. Shields

Pathology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A 6-year-old boy with known multisystem Langerhans cell histiocytosis developed photophobia, conjunctival injection, iris neovascularization, and an iridociliochoroidal mass. Fine-needle aspiration biopsy revealed mononucleated and multinucleate histiocytes that demonstrated positive immunostaining for CD68 and S100 consistent with Langerhans cell histiocytosis. Management with intracameral bevacizumab (1.25 mg/0.05 mL) resolved the iris neovascularization, and plaque radiotherapy (brachytherapy) resolved the mass rapidly and completely, preserving the patient's visual acuity and preventing glaucoma during the 10-month follow-up.

Original language	English
Pages (from-to)	534-537
Number of pages	4
Journal	Journal of AAPOS
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.jaapos.2010.10.007
State	Published - Dec 2010

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title = "Langerhans cell histiocytosis of the uvea with neovascular glaucoma: Diagnosis by fine-needle aspiration biopsy and management with intraocular bevacizumab and brachytherapy",

abstract = "A 6-year-old boy with known multisystem Langerhans cell histiocytosis developed photophobia, conjunctival injection, iris neovascularization, and an iridociliochoroidal mass. Fine-needle aspiration biopsy revealed mononucleated and multinucleate histiocytes that demonstrated positive immunostaining for CD68 and S100 consistent with Langerhans cell histiocytosis. Management with intracameral bevacizumab (1.25 mg/0.05 mL) resolved the iris neovascularization, and plaque radiotherapy (brachytherapy) resolved the mass rapidly and completely, preserving the patient's visual acuity and preventing glaucoma during the 10-month follow-up.",

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AU - Shields, Carol L.

AU - Hogarty, Michael D.

AU - Kligman, Brad E.

AU - Christian, Colleen

AU - Ehya, Hormoz

AU - Shields, Jerry A.

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AB - A 6-year-old boy with known multisystem Langerhans cell histiocytosis developed photophobia, conjunctival injection, iris neovascularization, and an iridociliochoroidal mass. Fine-needle aspiration biopsy revealed mononucleated and multinucleate histiocytes that demonstrated positive immunostaining for CD68 and S100 consistent with Langerhans cell histiocytosis. Management with intracameral bevacizumab (1.25 mg/0.05 mL) resolved the iris neovascularization, and plaque radiotherapy (brachytherapy) resolved the mass rapidly and completely, preserving the patient's visual acuity and preventing glaucoma during the 10-month follow-up.

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Langerhans cell histiocytosis of the uvea with neovascular glaucoma: Diagnosis by fine-needle aspiration biopsy and management with intraocular bevacizumab and brachytherapy

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