Abstract
A 6-year-old boy with known multisystem Langerhans cell histiocytosis developed photophobia, conjunctival injection, iris neovascularization, and an iridociliochoroidal mass. Fine-needle aspiration biopsy revealed mononucleated and multinucleate histiocytes that demonstrated positive immunostaining for CD68 and S100 consistent with Langerhans cell histiocytosis. Management with intracameral bevacizumab (1.25 mg/0.05 mL) resolved the iris neovascularization, and plaque radiotherapy (brachytherapy) resolved the mass rapidly and completely, preserving the patient's visual acuity and preventing glaucoma during the 10-month follow-up.
Original language | English |
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Pages (from-to) | 534-537 |
Number of pages | 4 |
Journal | Journal of AAPOS |
Volume | 14 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2010 |
Keywords
- Angiogenesis Inhibitors/administration & dosage
- Antibodies, Monoclonal, Humanized
- Antibodies, Monoclonal/administration & dosage
- Bevacizumab
- Biopsy, Fine-Needle
- Brachytherapy
- Child
- Combined Modality Therapy
- Glaucoma, Neovascular/drug therapy
- Histiocytosis, Langerhans-Cell/drug therapy
- Humans
- Injections, Intraocular
- Male
- Uvea/pathology