Ketosis versus carbotoxicity–metabolism determines the outcome of cancer immunotherapy

Aitziber Buqué; Lorenzo Galluzzi; Guido Kroemer

doi:10.1080/23723556.2020.1868266

Ketosis versus carbotoxicity–metabolism determines the outcome of cancer immunotherapy

Aitziber Buqué, Lorenzo Galluzzi, Guido Kroemer

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.

Original language	English
Article number	1868266
Journal	Molecular and Cellular Oncology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2020.1868266
State	Published - 2021
Externally published	Yes

Keywords

3-hydroxybutyrate
CTLA4
immune checkpoint inhibitors
ketogenic diet
PD-1
sucrose

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2020.1868266

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title = "Ketosis versus carbotoxicity–metabolism determines the outcome of cancer immunotherapy",

abstract = "Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.",

keywords = "3-hydroxybutyrate, CTLA4, immune checkpoint inhibitors, ketogenic diet, PD-1, sucrose",

author = "Aitziber Buqu{\'e} and Lorenzo Galluzzi and Guido Kroemer",

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year = "2021",

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language = "English",

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AU - Buqué, Aitziber

AU - Galluzzi, Lorenzo

AU - Kroemer, Guido

PY - 2021

Y1 - 2021

N2 - Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.

AB - Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high glucose levels appear to mediate immunosuppressive effects in preclinical tumor models. Recent data from Ferrere and colleagues point to the intriguing possibility that carbotoxicity may originate from the abolition of ketosis.

KW - 3-hydroxybutyrate

KW - CTLA4

KW - immune checkpoint inhibitors

KW - ketogenic diet

KW - PD-1

KW - sucrose

UR - http://www.scopus.com/inward/record.url?scp=85099474982&partnerID=8YFLogxK

U2 - 10.1080/23723556.2020.1868266

DO - 10.1080/23723556.2020.1868266

M3 - Comment/debate

C2 - 33553614

AN - SCOPUS:85099474982

SN - 2372-3556

VL - 8

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 1

M1 - 1868266

ER -

Ketosis versus carbotoxicity–metabolism determines the outcome of cancer immunotherapy

Abstract

Keywords

UN SDGs

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