TY - JOUR
T1 - Keeping it in check
T2 - Chronic viral infection and antiviral immunity in the brain
AU - Miller, Katelyn D.
AU - Schnell, Matthias J.
AU - Rall, G. F.
N1 - 1471-0048 Miller, Katelyn D Schnell, Matthias J Rall, Glenn F Journal Article England Nat Rev Neurosci. 2016 Dec;17(12):766-776. doi: 10.1038/nrn.2016.140. Epub 2016 Nov 4.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - It is becoming clear that the manner by which the immune response resolves or contains infection by a pathogen varies according to the tissue that is affected. Unlike many peripheral cell types, CNS neurons are generally non-renewable. Thus, the cytolytic and inflammatory strategies that are effective in controlling infections in the periphery could be damaging if deployed in the CNS. Perhaps for this reason, the immune response to some CNS viral infections favours maintenance of neuronal integrity and non-neurolytic viral control. This modified immune response - when combined with the unique anatomy and physiology of the CNS - provides an ideal environment for the maintenance of viral genomes, including those of RNA viruses. Therefore, it is possible that such viruses can reactivate long after initial viral exposure, contributing to CNS disease.
AB - It is becoming clear that the manner by which the immune response resolves or contains infection by a pathogen varies according to the tissue that is affected. Unlike many peripheral cell types, CNS neurons are generally non-renewable. Thus, the cytolytic and inflammatory strategies that are effective in controlling infections in the periphery could be damaging if deployed in the CNS. Perhaps for this reason, the immune response to some CNS viral infections favours maintenance of neuronal integrity and non-neurolytic viral control. This modified immune response - when combined with the unique anatomy and physiology of the CNS - provides an ideal environment for the maintenance of viral genomes, including those of RNA viruses. Therefore, it is possible that such viruses can reactivate long after initial viral exposure, contributing to CNS disease.
UR - http://www.scopus.com/inward/record.url?scp=84994067093&partnerID=8YFLogxK
U2 - 10.1038/nrn.2016.140
DO - 10.1038/nrn.2016.140
M3 - Article
C2 - 27811921
SN - 1471-003x
VL - 17
SP - 766
EP - 776
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 12
ER -