Abstract
DNA sequences of four human class II histocompatibility antigen α chain DNA sequences (derived from cDNA and genomic clones representing DC1α, DC4α, DXα and SBα) are presented and compared to DRα and to mouse I-Aα and I-Eα sequences. These data suggest possible mechanisms for the generation of polymorphism and the evolution of the DR, DC and SB families.
Original language | English |
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Pages (from-to) | 327-333 |
Number of pages | 7 |
Journal | Nature |
Volume | 308 |
Issue number | 5957 |
DOIs | |
State | Published - Mar 22 1984 |
Keywords
- Alleles
- Animals
- Base Sequence
- DNA/genetics
- Genes
- Genetic Variation
- HLA-DP Antigens
- HLA-DQ Antigens
- Histocompatibility Antigens Class II/genetics
- Humans
- Macromolecular Substances
- Mice
- Polymorphism, Genetic