Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC

Alfonso Bellacosa; Joseph R. Testa

doi:10.1016/0167-4781(96)00025-5

Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC

Alfonso Bellacosa, Joseph R. Testa

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Abstract

We report the isolation of a novel human cDNA encoding a putative transmembrane protein, TMC. The predicted protein sequence is highly conserved evolutionarily. The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary.

Original language	English
Pages (from-to)	137-141
Number of pages	5
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1306
Issue number	2-3
DOIs	https://doi.org/10.1016/0167-4781(96)00025-5
State	Published - May 2 1996

Keywords

Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 11
Conserved Sequence
DNA, Complementary
Hexosyltransferases
Humans
In Situ Hybridization, Fluorescence
Membrane Proteins/genetics
Molecular Sequence Data
Sequence Homology, Amino Acid

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10.1016/0167-4781(96)00025-5

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title = "Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC",

abstract = "We report the isolation of a novel human cDNA encoding a putative transmembrane protein, TMC. The predicted protein sequence is highly conserved evolutionarily. The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary.",

keywords = "Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 11, Conserved Sequence, DNA, Complementary, Hexosyltransferases, Humans, In Situ Hybridization, Fluorescence, Membrane Proteins/genetics, Molecular Sequence Data, Sequence Homology, Amino Acid",

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year = "1996",

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doi = "10.1016/0167-4781(96)00025-5",

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volume = "1306",

pages = "137--141",

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T1 - Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC

AU - Bellacosa, Alfonso

AU - Testa, Joseph R.

PY - 1996/5/2

Y1 - 1996/5/2

N2 - We report the isolation of a novel human cDNA encoding a putative transmembrane protein, TMC. The predicted protein sequence is highly conserved evolutionarily. The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary.

AB - We report the isolation of a novel human cDNA encoding a putative transmembrane protein, TMC. The predicted protein sequence is highly conserved evolutionarily. The cDNA clone was mapped to human chromosome 11q24-25 by fluorescence in situ hybridization. mRNA expression was observed in all tissues tested with the highest levels in testes and ovary.

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 11

KW - Conserved Sequence

KW - DNA, Complementary

KW - Hexosyltransferases

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Membrane Proteins/genetics

KW - Molecular Sequence Data

KW - Sequence Homology, Amino Acid

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U2 - 10.1016/0167-4781(96)00025-5

DO - 10.1016/0167-4781(96)00025-5

M3 - Article

C2 - 8634329

SN - 0167-4781

VL - 1306

SP - 137

EP - 141

JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

IS - 2-3

ER -

Isolation, characterization, and mapping to human chromosome 11q24-25 of a cDNA encoding a highly conserved putative transmembrane protein, TMC

Abstract

Keywords

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