Isochromosome (8q) in four patients with adenocarcinoma of the lung

Ikuo Miura; James Resau; Takafumi Tomiyasu; Joseph R. Testa

doi:10.1016/0165-4608(90)90121-P

Isochromosome (8q) in four patients with adenocarcinoma of the lung

Ikuo Miura, James Resau, Takafumi Tomiyasu, Joseph R. Testa

Cancer Prevention and Control (CPC)

University of Maryland

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We report an isochromosome, i(8q), in combination with many other cytogenetic changes in tumor cells from four patients with lung cancer. In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lung cancer. Among the few previously reported cytogenetic analyses of pulmonary adenocarcinomas, i(8q) has been observed in four additional patients. Therefore, i(8q) represents a recurring change in this specific type of lung cancer. In addition to i(8q), tumor cells from each of our four patients had different abnormalities of 17p, and two patients had alterations of 3p as well.

Original language	English
Pages (from-to)	203-207
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(90)90121-P
State	Published - Sep 1990

Keywords

Adenocarcinoma/genetics
Chromosome Aberrations
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 8
Female
Humans
Lung Neoplasms/genetics
Male
Middle Aged

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10.1016/0165-4608(90)90121-P

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title = "Isochromosome (8q) in four patients with adenocarcinoma of the lung",

abstract = "We report an isochromosome, i(8q), in combination with many other cytogenetic changes in tumor cells from four patients with lung cancer. In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lung cancer. Among the few previously reported cytogenetic analyses of pulmonary adenocarcinomas, i(8q) has been observed in four additional patients. Therefore, i(8q) represents a recurring change in this specific type of lung cancer. In addition to i(8q), tumor cells from each of our four patients had different abnormalities of 17p, and two patients had alterations of 3p as well.",

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AU - Miura, Ikuo

AU - Resau, James

AU - Tomiyasu, Takafumi

AU - Testa, Joseph R.

PY - 1990/9

Y1 - 1990/9

N2 - We report an isochromosome, i(8q), in combination with many other cytogenetic changes in tumor cells from four patients with lung cancer. In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lung cancer. Among the few previously reported cytogenetic analyses of pulmonary adenocarcinomas, i(8q) has been observed in four additional patients. Therefore, i(8q) represents a recurring change in this specific type of lung cancer. In addition to i(8q), tumor cells from each of our four patients had different abnormalities of 17p, and two patients had alterations of 3p as well.

AB - We report an isochromosome, i(8q), in combination with many other cytogenetic changes in tumor cells from four patients with lung cancer. In each case, the tumor subtype was adenocarcinoma. This isochromosome has not been identified in primary tumors from patients with other histological types of lung cancer. Among the few previously reported cytogenetic analyses of pulmonary adenocarcinomas, i(8q) has been observed in four additional patients. Therefore, i(8q) represents a recurring change in this specific type of lung cancer. In addition to i(8q), tumor cells from each of our four patients had different abnormalities of 17p, and two patients had alterations of 3p as well.

KW - Adenocarcinoma/genetics

KW - Chromosome Aberrations

KW - Chromosomes, Human, Pair 17

KW - Chromosomes, Human, Pair 3

KW - Chromosomes, Human, Pair 8

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KW - Humans

KW - Lung Neoplasms/genetics

KW - Male

KW - Middle Aged

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ER -

Isochromosome (8q) in four patients with adenocarcinoma of the lung

Abstract

Keywords

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