Abstract
Nine patients with advanced epithelial ovarian cancer, classified as either stage III with macrometastatic residual disease or stage IV, received combination chemotherapy in conjunction with ip rabbit-derived human ovarian antitumor serum (HOATS). The HOATS regimen consisted of the ip instillation of 100 ml of ovarian antitumor serum on Days 1 and 3 of the first chemotherapy cycle. Side effects attributable to HOATS were low-grade fever in three patients and diffuse skin rash in two. The 1-year cumulative survival was 87%, with a clinical response rate of 80%. No significant toxic reactions to HOATS have been observed. Continuation of the present study seems justified.
Original language | English |
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Pages (from-to) | 1981-1982 |
Number of pages | 2 |
Journal | Cancer Treatment Reports |
Volume | 66 |
Issue number | 11 |
State | Published - 1982 |
Keywords
- Adenocarcinoma/therapy
- Antibodies, Neoplasm/administration & dosage
- Antineoplastic Agents/administration & dosage
- Dermatitis/etiology
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Fever
- Humans
- Immunotherapy
- Injections, Intraperitoneal
- Ovarian Neoplasms/therapy