Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

Xiaojin Sha; Shu Meng; Xinyuan Li; Hang Xi; Massimo Maddaloni; David W. Pascual; Huimin Shan; Xiaohua Jiang; Hong Wang; Xiao Feng Yang

doi:10.1074/jbc.M115.663286

Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

Xiaojin Sha
, Shu Meng
, Xinyuan Li
, Hang Xi
, Massimo Maddaloni
, David W. Pascual
, Huimin Shan
, Xiaohua Jiang
, Hong Wang
, Xiao Feng Yang

Nuclear Dynamics and Cancer (NDC)

Temple University
University of Florida

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.

Original language	English
Pages (from-to)	19307-19318
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M115.663286
State	Published - Jul 31 2015

Keywords

Adult
Aged
Animals
Atherosclerosis/blood
Case-Control Studies
Cell Adhesion
Cells, Cultured
Endothelial Cells/immunology
Endothelium, Vascular/pathology
Escherichia coli Infections/blood
Female
Humans
Interleukins/physiology
Leukocytes/immunology
Lipopolysaccharides/pharmacology
MAP Kinase Signaling System
Male
Mice, Inbred C57BL
Middle Aged
Sepsis/blood
Transcription Factor AP-1/metabolism
Vascular Cell Adhesion Molecule-1/genetics
Young Adult

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10.1074/jbc.M115.663286

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title = "Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway",

abstract = "Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.",

keywords = "Adult, Aged, Animals, Atherosclerosis/blood, Case-Control Studies, Cell Adhesion, Cells, Cultured, Endothelial Cells/immunology, Endothelium, Vascular/pathology, Escherichia coli Infections/blood, Female, Humans, Interleukins/physiology, Leukocytes/immunology, Lipopolysaccharides/pharmacology, MAP Kinase Signaling System, Male, Mice, Inbred C57BL, Middle Aged, Sepsis/blood, Transcription Factor AP-1/metabolism, Vascular Cell Adhesion Molecule-1/genetics, Young Adult",

author = "Xiaojin Sha and Shu Meng and Xinyuan Li and Hang Xi and Massimo Maddaloni and Pascual, \{David W.\} and Huimin Shan and Xiaohua Jiang and Hong Wang and Yang, \{Xiao Feng\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jul,

day = "31",

doi = "10.1074/jbc.M115.663286",

language = "English",

volume = "290",

pages = "19307--19318",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

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TY - JOUR

T1 - Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

AU - Sha, Xiaojin

AU - Meng, Shu

AU - Li, Xinyuan

AU - Xi, Hang

AU - Maddaloni, Massimo

AU - Pascual, David W.

AU - Shan, Huimin

AU - Jiang, Xiaohua

AU - Wang, Hong

AU - Yang, Xiao Feng

PY - 2015/7/31

Y1 - 2015/7/31

N2 - Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.

AB - Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.

KW - Adult

KW - Aged

KW - Animals

KW - Atherosclerosis/blood

KW - Case-Control Studies

KW - Cell Adhesion

KW - Cells, Cultured

KW - Endothelial Cells/immunology

KW - Endothelium, Vascular/pathology

KW - Escherichia coli Infections/blood

KW - Female

KW - Humans

KW - Interleukins/physiology

KW - Leukocytes/immunology

KW - Lipopolysaccharides/pharmacology

KW - MAP Kinase Signaling System

KW - Male

KW - Mice, Inbred C57BL

KW - Middle Aged

KW - Sepsis/blood

KW - Transcription Factor AP-1/metabolism

KW - Vascular Cell Adhesion Molecule-1/genetics

KW - Young Adult

UR - https://www.scopus.com/pages/publications/84940480277

U2 - 10.1074/jbc.M115.663286

DO - 10.1074/jbc.M115.663286

M3 - Article

C2 - 26085094

AN - SCOPUS:84940480277

SN - 0021-9258

VL - 290

SP - 19307

EP - 19318

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 31

ER -

Interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP-1 Pathway

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Keywords

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