Abstract
Background: Interleukin-35 is a novel inhibitory cytokine. Results: Interleukin-35 inhibits vascular endothelial cell activation by suppressing MAPK-AP1-mediated VACM-1 expression in LPS-induced acute inflammation. Conclusion: Interleukin-35 suppresses acute vascular endothelium response. Significance: Interleukin-35 may be an attractive reagent for anti-inflammatory therapy.
Original language | English |
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Pages (from-to) | 19307-19318 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 31 |
DOIs | |
State | Published - Jul 31 2015 |
Externally published | Yes |