Abstract
Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.
| Original language | English |
|---|---|
| Pages (from-to) | 871-873 |
| Number of pages | 3 |
| Journal | Trends in Cancer |
| Volume | 9 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2023 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- cancer stem cells
- cancer/immunity coevolution
- CGAS
- CNV
- immunoevasion
- Signal Transduction
- Kidney Neoplasms/genetics
- Humans
- Nucleotidyltransferases/metabolism
- Interferon Type I/metabolism
- Carcinoma, Renal Cell/genetics
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