Interferon signaling restrains renal cell carcinoma heterogeneity

Peter Holicek; Jitka Fucikova; Lorenzo Galluzzi

doi:10.1016/j.trecan.2023.08.008

Interferon signaling restrains renal cell carcinoma heterogeneity

Peter Holicek, Jitka Fucikova, Lorenzo Galluzzi

Research output: Contribution to journal › Article › peer-review

Abstract

Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.

Original language	English
Pages (from-to)	871-873
Number of pages	3
Journal	Trends in Cancer
Volume	9
Issue number	11
DOIs	https://doi.org/10.1016/j.trecan.2023.08.008
State	Published - Nov 2023
Externally published	Yes

Keywords

cancer stem cells
cancer/immunity coevolution
CGAS
CNV
immunoevasion
Signal Transduction
Kidney Neoplasms/genetics
Humans
Nucleotidyltransferases/metabolism
Interferon Type I/metabolism
Carcinoma, Renal Cell/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trecan.2023.08.008

Cite this

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title = "Interferon signaling restrains renal cell carcinoma heterogeneity",

abstract = "Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.",

keywords = "cancer stem cells, cancer/immunity coevolution, CGAS, CNV, immunoevasion, Signal Transduction, Kidney Neoplasms/genetics, Humans, Nucleotidyltransferases/metabolism, Interferon Type I/metabolism, Carcinoma, Renal Cell/genetics",

author = "Peter Holicek and Jitka Fucikova and Lorenzo Galluzzi",

year = "2023",

month = nov,

doi = "10.1016/j.trecan.2023.08.008",

language = "English",

volume = "9",

pages = "871--873",

journal = "Trends in Cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "11",

}

TY - JOUR

T1 - Interferon signaling restrains renal cell carcinoma heterogeneity

AU - Holicek, Peter

AU - Fucikova, Jitka

AU - Galluzzi, Lorenzo

PY - 2023/11

Y1 - 2023/11

N2 - Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.

AB - Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling.

KW - cancer stem cells

KW - cancer/immunity coevolution

KW - CGAS

KW - CNV

KW - immunoevasion

KW - Signal Transduction

KW - Kidney Neoplasms/genetics

KW - Humans

KW - Nucleotidyltransferases/metabolism

KW - Interferon Type I/metabolism

KW - Carcinoma, Renal Cell/genetics

UR - http://www.scopus.com/inward/record.url?scp=85169512048&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2023.08.008

DO - 10.1016/j.trecan.2023.08.008

M3 - Article

C2 - 37658022

AN - SCOPUS:85169512048

SN - 2405-8033

VL - 9

SP - 871

EP - 873

JO - Trends in Cancer

JF - Trends in Cancer

IS - 11

ER -

Interferon signaling restrains renal cell carcinoma heterogeneity

Abstract

Keywords

UN SDGs

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