Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs

Uttam Satyal; Vishnu Dutt Sharma; Jennifer A. Shif; Marc A. Ilies

doi:10.1021/bk-2017-1271.ch009

Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs

Uttam Satyal, Vishnu Dutt Sharma, Jennifer A. Shif, Marc A. Ilies

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Amphiphilic block copolymers combining polyethylene glycol with hydrophobic biodegradable polyesters, such as PEG-PLA or PEG-PCL, can act in self-Assembled form as drug delivery systems (DDSs) with proved clinical efficiency. However, circulation time and biodistribution of these polymeric DDSs can be further improved by understanding the factors affecting their dynamic stability and degradation. We are presenting data revealing that micelles generated from interface-engineered PEG-PBO-PCL triblock copolymers can resist esterases present in blood better than micelles made out of standard PEGPCL congeners, but can be degraded faster than these ones by specific esterases over-expressed in tumors, thus showing selective stability blood/tumor.

Original language	English
Title of host publication	Control of Amphiphile Self-Assembling at the Molecular Level
Subtitle of host publication	Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications
Editors	Marc A. Ilies
Publisher	American Chemical Society
Pages	211-229
Number of pages	19
ISBN (Print)	9780841232747
DOIs	https://doi.org/10.1021/bk-2017-1271.ch009
State	Published - 2017
Externally published	Yes

Publication series

Name	ACS Symposium Series
Volume	1271
ISSN (Print)	0097-6156
ISSN (Electronic)	1947-5918

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10.1021/bk-2017-1271.ch009

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Satyal, U., Sharma, V. D., Shif, J. A., & Ilies, M. A. (2017). Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs. In M. A. Ilies (Ed.), Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications (pp. 211-229). (ACS Symposium Series; Vol. 1271). American Chemical Society. https://doi.org/10.1021/bk-2017-1271.ch009

Satyal, Uttam ; Sharma, Vishnu Dutt ; Shif, Jennifer A. et al. / Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs. Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. editor / Marc A. Ilies. American Chemical Society, 2017. pp. 211-229 (ACS Symposium Series).

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title = "Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs",

abstract = "Amphiphilic block copolymers combining polyethylene glycol with hydrophobic biodegradable polyesters, such as PEG-PLA or PEG-PCL, can act in self-Assembled form as drug delivery systems (DDSs) with proved clinical efficiency. However, circulation time and biodistribution of these polymeric DDSs can be further improved by understanding the factors affecting their dynamic stability and degradation. We are presenting data revealing that micelles generated from interface-engineered PEG-PBO-PCL triblock copolymers can resist esterases present in blood better than micelles made out of standard PEGPCL congeners, but can be degraded faster than these ones by specific esterases over-expressed in tumors, thus showing selective stability blood/tumor.",

author = "Uttam Satyal and Sharma, {Vishnu Dutt} and Shif, {Jennifer A.} and Ilies, {Marc A.}",

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Satyal, U, Sharma, VD, Shif, JA & Ilies, MA 2017, Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs. in MA Ilies (ed.), Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. ACS Symposium Series, vol. 1271, American Chemical Society, pp. 211-229. https://doi.org/10.1021/bk-2017-1271.ch009

Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs. / Satyal, Uttam; Sharma, Vishnu Dutt; Shif, Jennifer A. et al.
Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. ed. / Marc A. Ilies. American Chemical Society, 2017. p. 211-229 (ACS Symposium Series; Vol. 1271).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N2 - Amphiphilic block copolymers combining polyethylene glycol with hydrophobic biodegradable polyesters, such as PEG-PLA or PEG-PCL, can act in self-Assembled form as drug delivery systems (DDSs) with proved clinical efficiency. However, circulation time and biodistribution of these polymeric DDSs can be further improved by understanding the factors affecting their dynamic stability and degradation. We are presenting data revealing that micelles generated from interface-engineered PEG-PBO-PCL triblock copolymers can resist esterases present in blood better than micelles made out of standard PEGPCL congeners, but can be degraded faster than these ones by specific esterases over-expressed in tumors, thus showing selective stability blood/tumor.

AB - Amphiphilic block copolymers combining polyethylene glycol with hydrophobic biodegradable polyesters, such as PEG-PLA or PEG-PCL, can act in self-Assembled form as drug delivery systems (DDSs) with proved clinical efficiency. However, circulation time and biodistribution of these polymeric DDSs can be further improved by understanding the factors affecting their dynamic stability and degradation. We are presenting data revealing that micelles generated from interface-engineered PEG-PBO-PCL triblock copolymers can resist esterases present in blood better than micelles made out of standard PEGPCL congeners, but can be degraded faster than these ones by specific esterases over-expressed in tumors, thus showing selective stability blood/tumor.

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Satyal U, Sharma VD, Shif JA, Ilies MA. Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs. In Ilies MA, editor, Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. American Chemical Society. 2017. p. 211-229. (ACS Symposium Series). doi: 10.1021/bk-2017-1271.ch009

Interface-engineered amphiphilic block copolymers with tuned enzymatic resistance for controlled delivery of chemotherapeutic drugs

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