Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Karthik Devarajan; Camille Ragin; Bhawna Dubey; Maria Jackson; Charnita Zeigler-Johnson; Rafael E. Flores-Obando; Norma McFarlane-Anderson; Marshall K. Tulloch-Reid; William Aiken; Kevin Kimbro; Dominique Reed; La Creis R. Kidd; Denise Gibbs; Sudhir Kumar

doi:10.1002/pros.24067

Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Karthik Devarajan, Camille Ragin, Bhawna Dubey, Maria Jackson, Charnita Zeigler-Johnson, Rafael E. Flores-Obando, Norma McFarlane-Anderson, Marshall K. Tulloch-Reid, William Aiken, Kevin Kimbro, Dominique Reed, La Creis R. Kidd, Denise Gibbs, Sudhir Kumar

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

BACKGROUND: Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR-related SNPs in relation to PC risk among Jamaican men.

METHODS: This case-control study evaluates two TLR related SNPs in 356 Jamaican men (194 controls and 162 cases) with or without history of STIs using stepwise penalized logistic regression in multivariable analyses.

RESULTS: Age (odds ratio [OR] = 1.08; 95% confidence interval [CI]: 1.04-1>.12; p < .001) and IRF3_rs2304206 GG genotype (OR = 0.47; 95% CI: 0.29-0<.78; p = .003) modulated PC risk in people with history of STIs. In the population with no history of STIs, resulting interactions between risk factors did not survive correction for multiple hypothesis testing.

CONCLUSION: Overall, an interaction between the IFR3_rs2304206 variant and a history of exposure to STIs leads to greater decrease of PC risk than the presence of polymorphic genotype alone. These findings are suggestive and require further validation. Identification of gene variants along with detection of lifestyle behaviors may contribute to identification of men at a greater risk of PC development in the population.

Original language	English
Pages (from-to)	1365-1372
Number of pages	8
Journal	Prostate
Volume	80
Issue number	15
DOIs	https://doi.org/10.1002/pros.24067
State	Published - Nov 1 2020

Keywords

Adult
Aged
Aged, 80 and over
Case-Control Studies
Genetic Predisposition to Disease
Genotype
Humans
Jamaica
Male
Middle Aged
Pilot Projects
Polymorphism, Single Nucleotide
Prostatic Neoplasms/etiology
Risk Assessment
Risk Factors
Sexually Transmitted Diseases/complications
Toll-Like Receptors/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pros.24067

Cite this

Devarajan, K., Ragin, C., Dubey, B., Jackson, M., Zeigler-Johnson, C., Flores-Obando, R. E., McFarlane-Anderson, N., Tulloch-Reid, M. K., Aiken, W., Kimbro, K., Reed, D., Kidd, L. C. R., Gibbs, D., & Kumar, S. (2020). Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men. Prostate, 80(15), 1365-1372. https://doi.org/10.1002/pros.24067

@article{c2949de5c16b48199b81efed02f1c64c,

title = "Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men",

abstract = "BACKGROUND: Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR-related SNPs in relation to PC risk among Jamaican men.METHODS: This case-control study evaluates two TLR related SNPs in 356 Jamaican men (194 controls and 162 cases) with or without history of STIs using stepwise penalized logistic regression in multivariable analyses.RESULTS: Age (odds ratio [OR] = 1.08; 95% confidence interval [CI]: 1.04-1>.12; p < .001) and IRF3_rs2304206 GG genotype (OR = 0.47; 95% CI: 0.29-0<.78; p = .003) modulated PC risk in people with history of STIs. In the population with no history of STIs, resulting interactions between risk factors did not survive correction for multiple hypothesis testing.CONCLUSION: Overall, an interaction between the IFR3_rs2304206 variant and a history of exposure to STIs leads to greater decrease of PC risk than the presence of polymorphic genotype alone. These findings are suggestive and require further validation. Identification of gene variants along with detection of lifestyle behaviors may contribute to identification of men at a greater risk of PC development in the population.",

keywords = "Adult, Aged, Aged, 80 and over, Case-Control Studies, Genetic Predisposition to Disease, Genotype, Humans, Jamaica, Male, Middle Aged, Pilot Projects, Polymorphism, Single Nucleotide, Prostatic Neoplasms/etiology, Risk Assessment, Risk Factors, Sexually Transmitted Diseases/complications, Toll-Like Receptors/genetics",

author = "Karthik Devarajan and Camille Ragin and Bhawna Dubey and Maria Jackson and Charnita Zeigler-Johnson and Flores-Obando, {Rafael E.} and Norma McFarlane-Anderson and Tulloch-Reid, {Marshall K.} and William Aiken and Kevin Kimbro and Dominique Reed and Kidd, {La Creis R.} and Denise Gibbs and Sudhir Kumar",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

year = "2020",

month = nov,

day = "1",

doi = "10.1002/pros.24067",

language = "English",

volume = "80",

pages = "1365--1372",

journal = "Prostate",

issn = "0270-4137",

publisher = "Wiley-Liss Inc.",

number = "15",

}

Devarajan, K , Ragin, C, Dubey, B, Jackson, M, Zeigler-Johnson, C, Flores-Obando, RE, McFarlane-Anderson, N, Tulloch-Reid, MK, Aiken, W, Kimbro, K, Reed, D, Kidd, LCR, Gibbs, D & Kumar, S 2020, 'Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men', Prostate, vol. 80, no. 15, pp. 1365-1372. https://doi.org/10.1002/pros.24067

TY - JOUR

T1 - Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

AU - Devarajan, Karthik

AU - Ragin, Camille

AU - Dubey, Bhawna

AU - Jackson, Maria

AU - Zeigler-Johnson, Charnita

AU - Flores-Obando, Rafael E.

AU - McFarlane-Anderson, Norma

AU - Tulloch-Reid, Marshall K.

AU - Aiken, William

AU - Kimbro, Kevin

AU - Reed, Dominique

AU - Kidd, La Creis R.

AU - Gibbs, Denise

AU - Kumar, Sudhir

PY - 2020/11/1

Y1 - 2020/11/1

N2 - BACKGROUND: Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR-related SNPs in relation to PC risk among Jamaican men.METHODS: This case-control study evaluates two TLR related SNPs in 356 Jamaican men (194 controls and 162 cases) with or without history of STIs using stepwise penalized logistic regression in multivariable analyses.RESULTS: Age (odds ratio [OR] = 1.08; 95% confidence interval [CI]: 1.04-1>.12; p < .001) and IRF3_rs2304206 GG genotype (OR = 0.47; 95% CI: 0.29-0<.78; p = .003) modulated PC risk in people with history of STIs. In the population with no history of STIs, resulting interactions between risk factors did not survive correction for multiple hypothesis testing.CONCLUSION: Overall, an interaction between the IFR3_rs2304206 variant and a history of exposure to STIs leads to greater decrease of PC risk than the presence of polymorphic genotype alone. These findings are suggestive and require further validation. Identification of gene variants along with detection of lifestyle behaviors may contribute to identification of men at a greater risk of PC development in the population.

AB - BACKGROUND: Prostate cancer (PC) risk increases with African ancestry and a history of sexually transmitted infections (STIs). Also, single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes influence PC risk. This pilot study explores interactions between STIs and TLR-related SNPs in relation to PC risk among Jamaican men.METHODS: This case-control study evaluates two TLR related SNPs in 356 Jamaican men (194 controls and 162 cases) with or without history of STIs using stepwise penalized logistic regression in multivariable analyses.RESULTS: Age (odds ratio [OR] = 1.08; 95% confidence interval [CI]: 1.04-1>.12; p < .001) and IRF3_rs2304206 GG genotype (OR = 0.47; 95% CI: 0.29-0<.78; p = .003) modulated PC risk in people with history of STIs. In the population with no history of STIs, resulting interactions between risk factors did not survive correction for multiple hypothesis testing.CONCLUSION: Overall, an interaction between the IFR3_rs2304206 variant and a history of exposure to STIs leads to greater decrease of PC risk than the presence of polymorphic genotype alone. These findings are suggestive and require further validation. Identification of gene variants along with detection of lifestyle behaviors may contribute to identification of men at a greater risk of PC development in the population.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Jamaica

KW - Male

KW - Middle Aged

KW - Pilot Projects

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms/etiology

KW - Risk Assessment

KW - Risk Factors

KW - Sexually Transmitted Diseases/complications

KW - Toll-Like Receptors/genetics

UR - http://www.scopus.com/inward/record.url?scp=85090302592&partnerID=8YFLogxK

U2 - 10.1002/pros.24067

DO - 10.1002/pros.24067

M3 - Article

C2 - 32894795

SN - 0270-4137

VL - 80

SP - 1365

EP - 1372

JO - Prostate

JF - Prostate

IS - 15

ER -

Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Abstract

Keywords

UN SDGs

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Fox Chase Cancer Center: New Link Found Between Genetic Variant, Sexually Transmitted Infections, and Prostate Cancer Risk

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Interactive effect of TLR SNPs and exposure to sexually transmitted infections on prostate cancer risk in Jamaican men

Abstract

Keywords

UN SDGs

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Fox Chase Cancer Center: New Link Found Between Genetic Variant, Sexually Transmitted Infections, and Prostate Cancer Risk

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