Interaction between bisantrene and radiation

Enrique Hernandez, Neil B. Rosenshein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The interaction between Bisantrene, a new anthracene derivative, and radiation was studied in vitro. Chinese hamster lung (V-79-171) cells grown as monolayers were exposed to three different concentrations (0.4 mcg/ml, 2 mcg/ml, 10 mcg/ml) of Bisantrene for 120 min. during their exponential growth phase. Immediately after drug exposure, the cells were irradiated with escalating doses of radiation (100-1200 rad). Isoeffect curves (99% cell kill) were calculated using dose-survival curves generated for each modality. Curve I assumed that the agents act by independent mechanisms; Curve II assumed that the agents act by a similar mechanism. The dose combinations of the two modalities producing a 99% kill were plotted against the calculated isoeffect curves. The experimental points were found to lie along the calculated lines. Pre-treatment with Bisantrene prior to radiation resulted in an additive effect, similar to that reported with Adriamycin.

Original languageEnglish
Pages (from-to)1395-1399
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume11
Issue number7
DOIs
StatePublished - Jul 1985

Keywords

  • Animals
  • Anthracenes/pharmacology
  • Antibiotics, Antineoplastic/pharmacology
  • Cell Line
  • Cell Survival/drug effects
  • Cricetinae
  • Cricetulus
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • In Vitro Techniques

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