Abstract
The interaction between Bisantrene, a new anthracene derivative, and radiation was studied in vitro. Chinese hamster lung (V-79-171) cells grown as monolayers were exposed to three different concentrations (0.4 mcg/ml, 2 mcg/ml, 10 mcg/ml) of Bisantrene for 120 min. during their exponential growth phase. Immediately after drug exposure, the cells were irradiated with escalating doses of radiation (100-1200 rad). Isoeffect curves (99% cell kill) were calculated using dose-survival curves generated for each modality. Curve I assumed that the agents act by independent mechanisms; Curve II assumed that the agents act by a similar mechanism. The dose combinations of the two modalities producing a 99% kill were plotted against the calculated isoeffect curves. The experimental points were found to lie along the calculated lines. Pre-treatment with Bisantrene prior to radiation resulted in an additive effect, similar to that reported with Adriamycin.
Original language | English |
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Pages (from-to) | 1395-1399 |
Number of pages | 5 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 11 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1985 |
Keywords
- Animals
- Anthracenes/pharmacology
- Antibiotics, Antineoplastic/pharmacology
- Cell Line
- Cell Survival/drug effects
- Cricetinae
- Cricetulus
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- In Vitro Techniques