TY - JOUR
T1 - Integration of prostate cancer clinical data using an ontology
AU - Min, Hua
AU - Manion, Frank J.
AU - Goralczyk, Elizabeth
AU - Wong, Yu Ning
AU - Ross, Eric
AU - Beck, J. Robert
PY - 2009/12
Y1 - 2009/12
N2 - It is increasingly important for investigators to efficiently and effectively access, interpret, and analyze the data from diverse biological, literature, and annotation sources in a unified way. The heterogeneity of biomedical data and the lack of metadata are the primary sources of the difficulty for integration, presenting major challenges to effective search and retrieval of the information. As a proof of concept, the Prostate Cancer Ontology (PCO) is created for the development of the Prostate Cancer Information System (PCIS). PCIS is applied to demonstrate how the ontology is utilized to solve the semantic heterogeneity problem from the integration of two prostate cancer related database systems at the Fox Chase Cancer Center. As the results of the integration process, the semantic query language SPARQL is applied to perform the integrated queries across the two database systems based on PCO.
AB - It is increasingly important for investigators to efficiently and effectively access, interpret, and analyze the data from diverse biological, literature, and annotation sources in a unified way. The heterogeneity of biomedical data and the lack of metadata are the primary sources of the difficulty for integration, presenting major challenges to effective search and retrieval of the information. As a proof of concept, the Prostate Cancer Ontology (PCO) is created for the development of the Prostate Cancer Information System (PCIS). PCIS is applied to demonstrate how the ontology is utilized to solve the semantic heterogeneity problem from the integration of two prostate cancer related database systems at the Fox Chase Cancer Center. As the results of the integration process, the semantic query language SPARQL is applied to perform the integrated queries across the two database systems based on PCO.
KW - Data integration
KW - Knowledge sharing
KW - Ontology
KW - Semantic heterogeneity
UR - http://www.scopus.com/inward/record.url?scp=70350574680&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000271665800007&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.jbi.2009.05.007
DO - 10.1016/j.jbi.2009.05.007
M3 - Article
C2 - 19497389
SN - 1532-0464
VL - 42
SP - 1035
EP - 1045
JO - Journal of Biomedical Informatics
JF - Journal of Biomedical Informatics
IS - 6
ER -
