Inhibition of Heat Shock Transcription Factor Binding by a Linear Polyamide Binding in an Unusual 1:1 Mode

Rongsheng E. Wang; Raj K. Pandita; Jianfeng Cai; Clayton R. Hunt; John Stephen Taylor

doi:10.1002/cbic.201100524

Inhibition of Heat Shock Transcription Factor Binding by a Linear Polyamide Binding in an Unusual 1:1 Mode

Rongsheng E. Wang, Raj K. Pandita, Jianfeng Cai, Clayton R. Hunt, John Stephen Taylor

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Heat shock proteins (HSPs) are known to protect cells from heat, oxidative stress, and the cytotoxic effects of drugs, and thus can enhance cancer cell survival. As a result, HSPs are a newly emerging class of protein targets for chemotherapy. Among the various HSPs, the HSP70 family is the most highly conserved and prevalent. Herein we describe the development of a β-alanine rich linear polyamide that binds the GGA heat shock elements (HSEs) 3 and 4 in the HSP70 promoter in an unusual 1:1 mode and inhibits heat shock transcription factor 1 (HSF1) binding in vitro.

Original language	English
Pages (from-to)	97-104
Number of pages	8
Journal	ChemBioChem
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/cbic.201100524
State	Published - Jan 2 2012

Keywords

Binding Sites/drug effects
DNA-Binding Proteins/antagonists & inhibitors
Heat Shock Transcription Factors
Humans
Molecular Structure
Nylons/chemical synthesis
Protein Isoforms/antagonists & inhibitors
Structure-Activity Relationship
Transcription Factors/antagonists & inhibitors

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10.1002/cbic.201100524

Cite this

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title = "Inhibition of Heat Shock Transcription Factor Binding by a Linear Polyamide Binding in an Unusual 1:1 Mode",

abstract = "Heat shock proteins (HSPs) are known to protect cells from heat, oxidative stress, and the cytotoxic effects of drugs, and thus can enhance cancer cell survival. As a result, HSPs are a newly emerging class of protein targets for chemotherapy. Among the various HSPs, the HSP70 family is the most highly conserved and prevalent. Herein we describe the development of a β-alanine rich linear polyamide that binds the GGA heat shock elements (HSEs) 3 and 4 in the HSP70 promoter in an unusual 1:1 mode and inhibits heat shock transcription factor 1 (HSF1) binding in vitro.",

keywords = "Binding Sites/drug effects, DNA-Binding Proteins/antagonists \& inhibitors, Heat Shock Transcription Factors, Humans, Molecular Structure, Nylons/chemical synthesis, Protein Isoforms/antagonists \& inhibitors, Structure-Activity Relationship, Transcription Factors/antagonists \& inhibitors",

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doi = "10.1002/cbic.201100524",

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T1 - Inhibition of Heat Shock Transcription Factor Binding by a Linear Polyamide Binding in an Unusual 1:1 Mode

AU - Wang, Rongsheng E.

AU - Pandita, Raj K.

AU - Cai, Jianfeng

AU - Hunt, Clayton R.

AU - Taylor, John Stephen

PY - 2012/1/2

Y1 - 2012/1/2

N2 - Heat shock proteins (HSPs) are known to protect cells from heat, oxidative stress, and the cytotoxic effects of drugs, and thus can enhance cancer cell survival. As a result, HSPs are a newly emerging class of protein targets for chemotherapy. Among the various HSPs, the HSP70 family is the most highly conserved and prevalent. Herein we describe the development of a β-alanine rich linear polyamide that binds the GGA heat shock elements (HSEs) 3 and 4 in the HSP70 promoter in an unusual 1:1 mode and inhibits heat shock transcription factor 1 (HSF1) binding in vitro.

AB - Heat shock proteins (HSPs) are known to protect cells from heat, oxidative stress, and the cytotoxic effects of drugs, and thus can enhance cancer cell survival. As a result, HSPs are a newly emerging class of protein targets for chemotherapy. Among the various HSPs, the HSP70 family is the most highly conserved and prevalent. Herein we describe the development of a β-alanine rich linear polyamide that binds the GGA heat shock elements (HSEs) 3 and 4 in the HSP70 promoter in an unusual 1:1 mode and inhibits heat shock transcription factor 1 (HSF1) binding in vitro.

KW - Binding Sites/drug effects

KW - DNA-Binding Proteins/antagonists & inhibitors

KW - Heat Shock Transcription Factors

KW - Humans

KW - Molecular Structure

KW - Nylons/chemical synthesis

KW - Protein Isoforms/antagonists & inhibitors

KW - Structure-Activity Relationship

KW - Transcription Factors/antagonists & inhibitors

UR - https://www.scopus.com/pages/publications/84155192368

U2 - 10.1002/cbic.201100524

DO - 10.1002/cbic.201100524

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C2 - 22134972

SN - 1439-4227

VL - 13

SP - 97

EP - 104

JO - ChemBioChem

JF - ChemBioChem

IS - 1

ER -

Inhibition of Heat Shock Transcription Factor Binding by a Linear Polyamide Binding in an Unusual 1:1 Mode

Abstract

Keywords

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