Inflammation and mitophagy are mitochondrial checkpoints to aging

Emma Guilbaud; Kristopher A. Sarosiek; Lorenzo Galluzzi

doi:10.1038/s41467-024-47840-1

Inflammation and mitophagy are mitochondrial checkpoints to aging

Emma Guilbaud, Kristopher A. Sarosiek, Lorenzo Galluzzi

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

Original language	English
Article number	3375
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-47840-1
State	Published - Mar 20 2024
Externally published	Yes

Keywords

Aging/genetics
Humans
Inflammation
Mitochondria/genetics
Mitophagy

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10.1038/s41467-024-47840-1

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title = "Inflammation and mitophagy are mitochondrial checkpoints to aging",

abstract = "Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.",

keywords = "Aging/genetics, Humans, Inflammation, Mitochondria/genetics, Mitophagy",

author = "Emma Guilbaud and Sarosiek, {Kristopher A.} and Lorenzo Galluzzi",

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T1 - Inflammation and mitophagy are mitochondrial checkpoints to aging

AU - Guilbaud, Emma

AU - Sarosiek, Kristopher A.

AU - Galluzzi, Lorenzo

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/3/20

Y1 - 2024/3/20

N2 - Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

AB - Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

KW - Aging/genetics

KW - Humans

KW - Inflammation

KW - Mitochondria/genetics

KW - Mitophagy

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DO - 10.1038/s41467-024-47840-1

M3 - Comment/debate

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JO - Nature Communications

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Inflammation and mitophagy are mitochondrial checkpoints to aging

Abstract

Keywords

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New Findings from Weill Cornell Medicine in Science Provides New Insights (Inflammation and Mitophagy Are Mitochondrial Checkpoints To Aging)

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Inflammation and mitophagy are mitochondrial checkpoints to aging

Abstract

Keywords

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New Findings from Weill Cornell Medicine in Science Provides New Insights (Inflammation and Mitophagy Are Mitochondrial Checkpoints To Aging)

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