@inproceedings{9e3e72308c5c4cdbb406293e51356e56,
title = "In vivo light dosimetry for HPPH-mediated pleural PDT",
abstract = "This study examines the light fluence (rate) delivered to patients undergoing pleural PDT as a function of treatment time, treatment volume and surface area. The accuracy of treatment delivery is analyzed as a function of the calibration accuracies of each isotropic detector and the calibration integrating sphere. The patients studied here are enrolled in a Phase I clinical trial of HPPH-mediated PDT for the treatment of non-small cell lung cancer with pleural effusion. Patients are administered 4mg per kg body weight HPPH 24-48 hours before the surgery. Patients undergoing photodynamic therapy (PDT) are treated with light therapy with a fluence of 15-60 J/cm2 at 661nm. Fluence rate (mW/cm2) and cumulative fluence (J/cm2) is monitored at 7 different sites during the entire light treatment delivery. Isotropic detectors are used for in-vivo light dosimetry. The anisotropy of each isotropic detector was found to be within 15%. The mean fluence rate delivery and treatment time are recorded. A correlation between the treatment time and the treatment volume is established. The result can be used as a clinical guideline for future pleural PDT treatment.",
keywords = "Light dosimetry, Photodynamic therapy, Photofrin",
author = "Andreea Dimofte and Zhu, {Timothy C.} and Finlay, {Jarod C.} and Melissa Cullighan and Edmonds, {Christine E.} and Friedberg, {Joseph S.} and Keith Cengel and Hahn, {Stephen M.}",
year = "2010",
doi = "10.1117/12.851514",
language = "English",
isbn = "9780819479471",
series = "Proceedings of SPIE--the International Society for Optical Engineering",
booktitle = "Optical Methods for Tumor Treatment and Detection",
note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIX ; Conference date: 23-01-2010 Through 25-01-2010",
}
