In vitro effects of photodynamic therapy on Aspergillus fumigatus

Joseph S. Friedberg; Cynthia Skema; Eric D. Baum; Jeffrey Burdick; Sergei A. Vinogradov; David F. Wilson; Annamarie D. Horan; Irving Nachamkin

doi:10.1093/jac/48.1.105

In vitro effects of photodynamic therapy on Aspergillus fumigatus

Joseph S. Friedberg
, Cynthia Skema
, Eric D. Baum
, Jeffrey Burdick
, Sergei A. Vinogradov
, David F. Wilson
, Annamarie D. Horan
, Irving Nachamkin

Surgery

University of Pennsylvania
Thomas Jefferson University

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 × 10¹ cfu/mL with a light dose of 110 J/cm² and up to 2.7 × 10⁶ cfu/mL with a light dose of 385 J/cm².

Original language	English
Pages (from-to)	105-107
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	48
Issue number	1
DOIs	https://doi.org/10.1093/jac/48.1.105
State	Published - 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aspergillus fumigatus/drug effects
Photochemotherapy

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10.1093/jac/48.1.105

Cite this

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title = "In vitro effects of photodynamic therapy on Aspergillus fumigatus",

abstract = "Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 {\texttimes} 101 cfu/mL with a light dose of 110 J/cm2 and up to 2.7 {\texttimes} 106 cfu/mL with a light dose of 385 J/cm2.",

keywords = "Aspergillus fumigatus/drug effects, Photochemotherapy",

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T1 - In vitro effects of photodynamic therapy on Aspergillus fumigatus

AU - Friedberg, Joseph S.

AU - Skema, Cynthia

AU - Baum, Eric D.

AU - Burdick, Jeffrey

AU - Vinogradov, Sergei A.

AU - Wilson, David F.

AU - Horan, Annamarie D.

AU - Nachamkin, Irving

PY - 2001

Y1 - 2001

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AB - Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 × 101 cfu/mL with a light dose of 110 J/cm2 and up to 2.7 × 106 cfu/mL with a light dose of 385 J/cm2.

KW - Aspergillus fumigatus/drug effects

KW - Photochemotherapy

UR - https://www.scopus.com/pages/publications/0034916314

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AN - SCOPUS:0034916314

SN - 0305-7453

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 1

ER -

In vitro effects of photodynamic therapy on Aspergillus fumigatus

Abstract

UN SDGs

Keywords

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