In vitro effects of photodynamic therapy on Aspergillus fumigatus

Joseph S. Friedberg; Cynthia Skema; Eric D. Baum; Jeffrey Burdick; Sergei A. Vinogradov; David F. Wilson; Annamarie D. Horan; Irving Nachamkin

doi:10.1093/jac/48.1.105

In vitro effects of photodynamic therapy on Aspergillus fumigatus

Joseph S. Friedberg, Cynthia Skema, Eric D. Baum, Jeffrey Burdick, Sergei A. Vinogradov, David F. Wilson, Annamarie D. Horan, Irving Nachamkin

Surgery

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 × 10¹ cfu/mL with a light dose of 110 J/cm² and up to 2.7 × 10⁶ cfu/mL with a light dose of 385 J/cm².

Original language	English
Pages (from-to)	105-107
Number of pages	3
Journal	Journal of Antimicrobial Chemotherapy
Volume	48
Issue number	1
DOIs	https://doi.org/10.1093/jac/48.1.105
State	Published - 2001

Keywords

Aspergillus fumigatus/drug effects
Photochemotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/jac/48.1.105

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abstract = "Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 × 101 cfu/mL with a light dose of 110 J/cm2 and up to 2.7 × 106 cfu/mL with a light dose of 385 J/cm2.",

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AU - Friedberg, Joseph S.

AU - Skema, Cynthia

AU - Baum, Eric D.

AU - Burdick, Jeffrey

AU - Vinogradov, Sergei A.

AU - Wilson, David F.

AU - Horan, Annamarie D.

AU - Nachamkin, Irving

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In vitro effects of photodynamic therapy on Aspergillus fumigatus

Abstract

Keywords

UN SDGs

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