Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agents

Giulia Petroni, Lorenzo Galluzzi

Research output: Contribution to journalEditorial

20 Scopus citations

Abstract

Radiation therapy (RT) and cyclin-dependent kinase 4/6 (CDK4/6) inhibitors mediate poorly overlapping cytostatic and immunostimulatory effects, suggesting that combinatorial regimens may enable supra-additive tumor control. Our preclinical findings demonstrate that administration schedule stands out as a major determinant of efficacy when RT and CDK4/6 inhibitors are combined for breast cancer therapy.

Original languageEnglish
Article number1889101
Pages (from-to)1889101
JournalOncoimmunology
Volume10
Issue number1
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • 4T1 cells
  • immune checkpoint inhibitors
  • MCF7 cells
  • MPA/DMBA-driven mammary carcinomas
  • targeted anticancer agents
  • TS/A cells
  • Cytostatic Agents
  • Humans
  • Female
  • Cyclin-Dependent Kinase 4
  • Breast Neoplasms/drug therapy
  • Cyclin-Dependent Kinase 6

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