Immunotherapy for breast cancer: Current and future strategies

Austin D. Williams; Kyle K. Payne; Avery D. Posey; Christine Hill; Jose Conejo-Garcia; Carl H. June; Julia Tchou

doi:10.1007/s40137-017-0194-1

Immunotherapy for breast cancer: Current and future strategies

Austin D. Williams, Kyle K. Payne, Avery D. Posey, Christine Hill, Jose Conejo-Garcia, Carl H. June, Julia Tchou

Surgery

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Purpose of Review The breast tumor microenvironment is immunosuppressive and is increasingly recognized to play a significant role in tumorigenesis. A deeper understanding of normal and aberrant interactions between malignant and immune cells has allowed researchers to harness the immune system with novel immunotherapy strategies, many of which have shown promise in breast cancer. This review discusses the application of immunotherapy to the treatment of breast cancer. Recent Findings Both basic science and clinical trial data are rapidly developing in the use of immunotherapy for breast cancer. The current clinical trial landscape includes therapeutic vaccines, immune checkpoint blockade, anti-bodies, cytokines, and adoptive cell therapy. Summary Despite early failures, the application of immunotherapeutic strategies to the treatment of breast cancer holds promise.

Original language	English
Article number	31
Journal	Current Surgery Reports
Volume	5
Issue number	12
DOIs	https://doi.org/10.1007/s40137-017-0194-1
State	Published - Dec 2017

Keywords

Breast cancer
Cancer vaccines
Chimeric antigen receptor T cells (CAR T)
Immune checkpoint
Immunotherapy
Oncolytic viruses

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s40137-017-0194-1

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title = "Immunotherapy for breast cancer: Current and future strategies",

abstract = "Purpose of Review The breast tumor microenvironment is immunosuppressive and is increasingly recognized to play a significant role in tumorigenesis. A deeper understanding of normal and aberrant interactions between malignant and immune cells has allowed researchers to harness the immune system with novel immunotherapy strategies, many of which have shown promise in breast cancer. This review discusses the application of immunotherapy to the treatment of breast cancer. Recent Findings Both basic science and clinical trial data are rapidly developing in the use of immunotherapy for breast cancer. The current clinical trial landscape includes therapeutic vaccines, immune checkpoint blockade, anti-bodies, cytokines, and adoptive cell therapy. Summary Despite early failures, the application of immunotherapeutic strategies to the treatment of breast cancer holds promise.",

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AU - Williams, Austin D.

AU - Payne, Kyle K.

AU - Posey, Avery D.

AU - Hill, Christine

AU - Conejo-Garcia, Jose

AU - June, Carl H.

AU - Tchou, Julia

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N2 - Purpose of Review The breast tumor microenvironment is immunosuppressive and is increasingly recognized to play a significant role in tumorigenesis. A deeper understanding of normal and aberrant interactions between malignant and immune cells has allowed researchers to harness the immune system with novel immunotherapy strategies, many of which have shown promise in breast cancer. This review discusses the application of immunotherapy to the treatment of breast cancer. Recent Findings Both basic science and clinical trial data are rapidly developing in the use of immunotherapy for breast cancer. The current clinical trial landscape includes therapeutic vaccines, immune checkpoint blockade, anti-bodies, cytokines, and adoptive cell therapy. Summary Despite early failures, the application of immunotherapeutic strategies to the treatment of breast cancer holds promise.

AB - Purpose of Review The breast tumor microenvironment is immunosuppressive and is increasingly recognized to play a significant role in tumorigenesis. A deeper understanding of normal and aberrant interactions between malignant and immune cells has allowed researchers to harness the immune system with novel immunotherapy strategies, many of which have shown promise in breast cancer. This review discusses the application of immunotherapy to the treatment of breast cancer. Recent Findings Both basic science and clinical trial data are rapidly developing in the use of immunotherapy for breast cancer. The current clinical trial landscape includes therapeutic vaccines, immune checkpoint blockade, anti-bodies, cytokines, and adoptive cell therapy. Summary Despite early failures, the application of immunotherapeutic strategies to the treatment of breast cancer holds promise.

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KW - Cancer vaccines

KW - Chimeric antigen receptor T cells (CAR T)

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KW - Immunotherapy

KW - Oncolytic viruses

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Immunotherapy for breast cancer: Current and future strategies

Abstract

Keywords

UN SDGs

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