TY - JOUR
T1 - Immunomodulation by anticancer cell cycle inhibitors
AU - Petroni, Giulia
AU - Formenti, Silvia C.
AU - Chen-Kiang, Selina
AU - Galluzzi, Lorenzo
N1 - Publisher Copyright:
© 2020, Springer Nature Limited.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent kinase 4 (CDK4) and CDK6, have attracted considerable interest as potential targets for cancer therapy. In this context, multiple inhibitors of CDK4 and CDK6 have been developed, including three small molecules (palbociclib, abemaciclib and ribociclib) that are currently approved for the treatment of patients with breast cancer and are being extensively tested in individuals with other solid and haematological malignancies. Accumulating preclinical and clinical evidence indicates that the anticancer activity of CDK4/CDK6 inhibitors results not only from their ability to block the cell cycle in malignant cells but also from a range of immunostimulatory effects. In this Review, we discuss the ability of anticancer cell cycle inhibitors to modulate various immune functions in support of effective antitumour immunity.
AB - Cell cycle proteins that are often dysregulated in malignant cells, such as cyclin-dependent kinase 4 (CDK4) and CDK6, have attracted considerable interest as potential targets for cancer therapy. In this context, multiple inhibitors of CDK4 and CDK6 have been developed, including three small molecules (palbociclib, abemaciclib and ribociclib) that are currently approved for the treatment of patients with breast cancer and are being extensively tested in individuals with other solid and haematological malignancies. Accumulating preclinical and clinical evidence indicates that the anticancer activity of CDK4/CDK6 inhibitors results not only from their ability to block the cell cycle in malignant cells but also from a range of immunostimulatory effects. In this Review, we discuss the ability of anticancer cell cycle inhibitors to modulate various immune functions in support of effective antitumour immunity.
UR - http://www.scopus.com/inward/record.url?scp=85084204293&partnerID=8YFLogxK
U2 - 10.1038/s41577-020-0300-y
DO - 10.1038/s41577-020-0300-y
M3 - Review article
C2 - 32346095
AN - SCOPUS:85084204293
SN - 1474-1733
VL - 20
SP - 669
EP - 679
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 11
ER -