Immunologically relevant effects of radiation therapy on the tumor microenvironment

Claudia Galassi; Vanessa Klapp; Silvia C. Formenti; Sandra Demaria; Lorenzo Galluzzi

doi:10.1042/EBC20220248

Immunologically relevant effects of radiation therapy on the tumor microenvironment

Claudia Galassi, Vanessa Klapp, Silvia C. Formenti, Sandra Demaria, Lorenzo Galluzzi

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

Original language	English
Pages (from-to)	979-989
Number of pages	11
Journal	Essays in Biochemistry
Volume	67
Issue number	6
DOIs	https://doi.org/10.1042/EBC20220248
State	Published - Sep 2023
Externally published	Yes

Keywords

Antineoplastic Agents
Humans
Neoplasms/radiotherapy
Tumor Microenvironment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1042/EBC20220248

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title = "Immunologically relevant effects of radiation therapy on the tumor microenvironment",

abstract = "Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.",

keywords = "Antineoplastic Agents, Humans, Neoplasms/radiotherapy, Tumor Microenvironment",

author = "Claudia Galassi and Vanessa Klapp and Formenti, {Silvia C.} and Sandra Demaria and Lorenzo Galluzzi",

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year = "2023",

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language = "English",

volume = "67",

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T1 - Immunologically relevant effects of radiation therapy on the tumor microenvironment

AU - Galassi, Claudia

AU - Klapp, Vanessa

AU - Formenti, Silvia C.

AU - Demaria, Sandra

AU - Galluzzi, Lorenzo

PY - 2023/9

Y1 - 2023/9

N2 - Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

AB - Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.

KW - Antineoplastic Agents

KW - Humans

KW - Neoplasms/radiotherapy

KW - Tumor Microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85173566932&partnerID=8YFLogxK

U2 - 10.1042/EBC20220248

DO - 10.1042/EBC20220248

M3 - Review article

C2 - 37199227

AN - SCOPUS:85173566932

SN - 0071-1365

VL - 67

SP - 979

EP - 989

JO - Essays in Biochemistry

JF - Essays in Biochemistry

IS - 6

ER -

Immunologically relevant effects of radiation therapy on the tumor microenvironment

Abstract

Keywords

UN SDGs

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