Immunogenicity of cell death driven by immune effectors

Lorenzo Galluzzi; Giulia Petroni; Guido Kroemer

doi:10.1136/jitc-2020-000802

Immunogenicity of cell death driven by immune effectors

Lorenzo Galluzzi, Giulia Petroni, Guido Kroemer

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.

Original language	English
Article number	e000802
Journal	Journal for ImmunoTherapy of Cancer
Volume	8
Issue number	1
DOIs	https://doi.org/10.1136/jitc-2020-000802
State	Published - Apr 5 2020
Externally published	Yes

Keywords

CD8-Positive T-Lymphocytes
cytotoxicity, immunologic
natural killer T-cells
receptors, chimeric antigen

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/jitc-2020-000802

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abstract = "Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.",

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AU - Petroni, Giulia

AU - Kroemer, Guido

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2020/4/5

Y1 - 2020/4/5

N2 - Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.

AB - Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic per se has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a bona fide variant of immunogenic cell death.

KW - CD8-Positive T-Lymphocytes

KW - cytotoxicity, immunologic

KW - natural killer T-cells

KW - receptors, chimeric antigen

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M3 - Review article

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IS - 1

M1 - e000802

ER -

Immunogenicity of cell death driven by immune effectors

Abstract

Keywords

UN SDGs

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