Immunogenic cell death in cancer: concept and therapeutic implications

Lorenzo Galluzzi; Oliver Kepp; Erik Hett; Guido Kroemer; Francesco M. Marincola

doi:10.1186/s12967-023-04017-6

Immunogenic cell death in cancer: concept and therapeutic implications

Lorenzo Galluzzi
, Oliver Kepp
, Erik Hett
, Guido Kroemer
, Francesco M. Marincola

Cornell University
Université Paris-Sud
Sonata Therapeutics
Centre de Recherche des Cordeliers
Assistance publique – Hôpitaux de Paris
Kite Pharma Inc.

Research output: Contribution to journal › Review article › peer-review

158 Scopus citations

Abstract

Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.

Original language	English
Article number	162
Pages (from-to)	162
Journal	Journal of Translational Medicine
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12967-023-04017-6
State	Published - Feb 2 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Cell Death
Cell Differentiation
Homeostasis
Immunogenic Cell Death
Mammals
Neoplasms/therapy

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10.1186/s12967-023-04017-6

Cite this

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title = "Immunogenic cell death in cancer: concept and therapeutic implications",

abstract = "Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.",

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T1 - Immunogenic cell death in cancer

T2 - concept and therapeutic implications

AU - Galluzzi, Lorenzo

AU - Kepp, Oliver

AU - Hett, Erik

AU - Kroemer, Guido

AU - Marincola, Francesco M.

PY - 2023/2/2

Y1 - 2023/2/2

N2 - Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.

AB - Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it should be conceptually differentiated from instances of immunostimulation or inflammatory responses that do not mechanistically depend on cellular demise. Here, we critically discuss key conceptual and mechanistic aspects of ICD and its implications for cancer (immuno)therapy.

KW - Animals

KW - Cell Death

KW - Cell Differentiation

KW - Homeostasis

KW - Immunogenic Cell Death

KW - Mammals

KW - Neoplasms/therapy

UR - https://www.scopus.com/pages/publications/85149318534

U2 - 10.1186/s12967-023-04017-6

DO - 10.1186/s12967-023-04017-6

M3 - Review article

C2 - 36864446

AN - SCOPUS:85149318534

SN - 1479-5876

VL - 21

SP - 162

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

IS - 1

M1 - 162

ER -

Immunogenic cell death in cancer: concept and therapeutic implications

Abstract

UN SDGs

Keywords

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