IL-1 can act as number one

Ana M. Gamero; Joost J. Oppenheim

doi:10.1016/j.immuni.2005.12.007

IL-1 can act as number one

Ana M. Gamero
, Joost J. Oppenheim

National Institutes of Health

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.

Original language	English
Pages (from-to)	16-17
Number of pages	2
Journal	Immunity
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2005.12.007
State	Published - Jan 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adaptor Proteins, Signal Transducing/genetics
Animals
Interleukin-1/metabolism
Mice
Myeloid Differentiation Factor 88
Receptors, Interleukin-1/genetics
Staphylococcal Infections/genetics
Staphylococcus aureus

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10.1016/j.immuni.2005.12.007

Cite this

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title = "IL-1 can act as number one",

abstract = "Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.",

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volume = "24",

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journal = "Immunity",

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AU - Gamero, Ana M.

AU - Oppenheim, Joost J.

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AB - Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.

KW - Adaptor Proteins, Signal Transducing/genetics

KW - Animals

KW - Interleukin-1/metabolism

KW - Mice

KW - Myeloid Differentiation Factor 88

KW - Receptors, Interleukin-1/genetics

KW - Staphylococcal Infections/genetics

KW - Staphylococcus aureus

UR - https://www.scopus.com/pages/publications/30444451629

U2 - 10.1016/j.immuni.2005.12.007

DO - 10.1016/j.immuni.2005.12.007

M3 - Short survey

C2 - 16413919

AN - SCOPUS:30444451629

SN - 1074-7613

VL - 24

SP - 16

EP - 17

JO - Immunity

JF - Immunity

IS - 1

ER -

IL-1 can act as number one

Abstract

UN SDGs

Keywords

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