IL-1 can act as number one

Ana M. Gamero, Joost J. Oppenheim

Research output: Contribution to journalShort surveypeer-review

19 Scopus citations

Abstract

Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.

Original languageEnglish
Pages (from-to)16-17
Number of pages2
JournalImmunity
Volume24
Issue number1
DOIs
StatePublished - Jan 2006

Keywords

  • Adaptor Proteins, Signal Transducing/genetics
  • Animals
  • Interleukin-1/metabolism
  • Mice
  • Myeloid Differentiation Factor 88
  • Receptors, Interleukin-1/genetics
  • Staphylococcal Infections/genetics
  • Staphylococcus aureus

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