Abstract
Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.
Original language | English |
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Pages (from-to) | 16-17 |
Number of pages | 2 |
Journal | Immunity |
Volume | 24 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2006 |
Keywords
- Adaptor Proteins, Signal Transducing/genetics
- Animals
- Interleukin-1/metabolism
- Mice
- Myeloid Differentiation Factor 88
- Receptors, Interleukin-1/genetics
- Staphylococcal Infections/genetics
- Staphylococcus aureus