Abstract
Human papillomavirus (HPV) is now considered a major causative agent in oropharyngeal squamous cell carcinoma (OP-SCC). The incidence of HPV1 OP-SCC is increasing dramatically, is higher in men, and now is more common than cervical cancer in the United States. HPV1 OP-SCC usually present as locally advanced, stage IV cancers, requiring intensive treatment with surgery, chemotherapy, and/or radiation that can cause tremendous morbidity. HPV vaccination is predicted to prevent HPV1 OP-SCC because more than 90% of cases are caused by vaccine-type HPV. However, current vaccination rates are not yet high enough to be effective in preventing HPV-associated malignancies at a population level.
| Original language | English |
|---|---|
| Pages (from-to) | 489-501 |
| Number of pages | 13 |
| Journal | Adolescent Medicine: State of the Art Reviews |
| Volume | 25 |
| Issue number | 2 |
| State | Published - Aug 2014 |
Keywords
- Adolescent
- Capsid Proteins/metabolism
- Carcinoma, Squamous Cell/epidemiology
- Combined Modality Therapy
- Head and Neck Neoplasms/epidemiology
- Humans
- Mass Screening
- Oncogene Proteins/metabolism
- Papillomavirus Infections/diagnosis
- Papillomavirus Vaccines/administration & dosage
- Prognosis
- Squamous Cell Carcinoma of Head and Neck
- Time Factors
