TY - JOUR
T1 - Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity
AU - Bocchetta, Maurizio
AU - Di Resta, Ilaria
AU - Powers, Amy
AU - Fresco, Raoul
AU - Tosolini, Alessandra
AU - Testa, Joseph R.
AU - Pass, Harvey I.
AU - Rizzo, Paola
AU - Carbone, Michele
PY - 2000/8/29
Y1 - 2000/8/29
N2 - Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the semipermissive infection thought to be characteristic of human cells. Mesothelial cells are uniformly infected but not lysed by SV40, a mechanism related to p53, and undergo cell transformation at an extremely high rate. Exposure of mesothelial cells to asbestos complemented SV40 mutants in transformation. Our data provide a mechanistic explanation for the ability of SV40 to transform mesothelial cells preferentially and indicate that asbestos and SV40 may be cocarcinogens.
AB - Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the semipermissive infection thought to be characteristic of human cells. Mesothelial cells are uniformly infected but not lysed by SV40, a mechanism related to p53, and undergo cell transformation at an extremely high rate. Exposure of mesothelial cells to asbestos complemented SV40 mutants in transformation. Our data provide a mechanistic explanation for the ability of SV40 to transform mesothelial cells preferentially and indicate that asbestos and SV40 may be cocarcinogens.
KW - Asbestos/toxicity
KW - Carcinogens/toxicity
KW - Cell Transformation, Neoplastic
KW - Cells, Cultured
KW - Epithelial Cells/drug effects
KW - Fibroblasts/cytology
KW - Humans
KW - Mesothelioma/etiology
KW - Simian virus 40
KW - Tumor Suppressor Protein p53/genetics
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UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000089067500072&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1073/pnas.170207097
DO - 10.1073/pnas.170207097
M3 - Article
C2 - 10954737
SN - 0027-8424
VL - 97
SP - 10214
EP - 10219
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 18
ER -