Abstract
This chapter contains sections titled: Introduction The concept of homology modeling How do homologous protein arise? The purposes of homology modeling The effect of the genome projects Input data Methods Modeling at different levels of complexity Loop modeling Side-chain modeling Methods for complete modeling Results Range of targets Example: amyloid precursor protein β-secretase Strengths and limitations Validation Side-chain prediction accuracy The CASP meetings Protein health Availability Appendix Backbone conformations Side-chain conformational analysis.
| Original language | English |
|---|---|
| Title of host publication | Bioinformatics - From Genomes to Drugs |
| Subtitle of host publication | Volume I: Basic Technologies: Volume II: Applications |
| Publisher | wiley |
| Pages | 145-235 |
| Number of pages | 91 |
| Volume | 1 |
| ISBN (Electronic) | 9783527601486 |
| ISBN (Print) | 3527299882, 9783527299881 |
| DOIs | |
| State | Published - Jan 1 2004 |
Keywords
- Amyloid β-secretase
- Homology modeling
- Loop modeling
- Side-chain modeling