Homologous Recombination and Replication Fork Protection: BRCA2 and More!

Weiran Feng; Maria Jasin

doi:10.1101/sqb.2017.82.035006

Homologous Recombination and Replication Fork Protection: BRCA2 and More!

Weiran Feng
, Maria Jasin

Memorial Sloan-Kettering Cancer Center

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

53 Scopus citations

Abstract

BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.

Original language	English
Title of host publication	Chromosome Segregation And Structure, Vol 82, 2017
Editors	D Stewart, B Stillman
Pages	329-338
Number of pages	10
Volume	82
DOIs	https://doi.org/10.1101/sqb.2017.82.035006
State	Published - 2017

Publication series

Name	Cold Spring Harbor symposia on quantitative biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1101/sqb.2017.82.035006

Cite this

@inproceedings{ccb4ffb456b8411dba55784d64f58cd7,

title = "Homologous Recombination and Replication Fork Protection: BRCA2 and More!",

abstract = "BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.",

author = "Weiran Feng and Maria Jasin",

note = "Publisher Copyright: {\textcopyright} 2017 Feng and Jasin; Published by Cold Spring Harbor Laboratory Press.",

year = "2017",

doi = "10.1101/sqb.2017.82.035006",

language = "English",

volume = "82",

series = "Cold Spring Harbor symposia on quantitative biology",

pages = "329--338",

editor = "D Stewart and B Stillman",

booktitle = "Chromosome Segregation And Structure, Vol 82, 2017",

}

TY - GEN

T1 - Homologous Recombination and Replication Fork Protection

T2 - BRCA2 and More!

AU - Feng, Weiran

AU - Jasin, Maria

PY - 2017

Y1 - 2017

N2 - BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.

AB - BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.

UR - https://www.scopus.com/pages/publications/85054878872

U2 - 10.1101/sqb.2017.82.035006

DO - 10.1101/sqb.2017.82.035006

M3 - Conference contribution

C2 - 29686033

VL - 82

T3 - Cold Spring Harbor symposia on quantitative biology

SP - 329

EP - 338

BT - Chromosome Segregation And Structure, Vol 82, 2017

A2 - Stewart, D

A2 - Stillman, B

ER -

Homologous Recombination and Replication Fork Protection: BRCA2 and More!

Abstract

Publication series

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this