TY - GEN
T1 - Homologous Recombination and Replication Fork Protection
T2 - BRCA2 and More!
AU - Feng, Weiran
AU - Jasin, Maria
N1 - © 2017 Feng and Jasin; Published by Cold Spring Harbor Laboratory Press.
PY - 2017
Y1 - 2017
N2 - BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.
AB - BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000484900900031&DestLinkType=FullRecord&DestApp=WOS_CPL
UR - http://www.scopus.com/inward/record.url?scp=85054878872&partnerID=8YFLogxK
U2 - 10.1101/sqb.2017.82.035006
DO - 10.1101/sqb.2017.82.035006
M3 - Conference contribution
C2 - 29686033
VL - 82
T3 - Cold Spring Harbor symposia on quantitative biology
SP - 329
EP - 338
BT - Chromosome Segregation And Structure, Vol 82, 2017
A2 - Stewart, D
A2 - Stillman, B
ER -