Homologous Recombination and Replication Fork Protection: BRCA2 and More!

Weiran Feng, Maria Jasin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

49 Scopus citations

Abstract

BRCA2 is a breast and ovarian tumor suppressor that guards against genome instability, a hallmark of cancer. Significant progress has been made in improving our understanding of BRCA2 function from biochemical, cellular, and mouse studies. The knowledge gained has been actively exploited to develop therapeutic strategies, including PARP inhibition, which has shown promising clinical outcomes. Recently, tremendous excitement has been generated by the findings of the roles of BRCA2 and other proteins in suppressing replication stress through homologous recombination and in the protection of stalled replication forks. Processes such as mitotic DNA synthesis and fork reversal have taken center stage in these studies. Here, we discuss our recent findings in the context of these advances.

Original languageEnglish
Title of host publicationChromosome Segregation And Structure, Vol 82, 2017
EditorsD Stewart, B Stillman
Pages329-338
Number of pages10
Volume82
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameCold Spring Harbor symposia on quantitative biology

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