Hit 'Em Where They Live: Targeting the Cancer Stem Cell Niche

Zeng Jie Yang; Robert J. Wechsler-Reya

doi:10.1016/j.ccr.2006.12.007

Hit 'Em Where They Live: Targeting the Cancer Stem Cell Niche

Zeng Jie Yang, Robert J. Wechsler-Reya

Duke University

Research output: Contribution to journal › Review article › peer-review

126 Scopus citations

Abstract

Cancer stem cells (CSCs) are thought to be critical for initiation and propagation of many types of cancer. Because these cells are resistant to conventional therapies, they have been very difficult to eliminate. A study in this issue of Cancer Cell suggests that brain tumor CSCs live in a "vascular niche" that promotes their long-term growth and self-renewal. Disrupting this niche impairs CSC self-renewal and thereby significantly inhibits the growth of tumors. Targeting the unique microenvironment of CSCs may be the key to effective cancer therapy.

Original language	English
Pages (from-to)	3-5
Number of pages	3
Journal	Cancer Cell
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2006.12.007
State	Published - Jan 2007

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10.1016/j.ccr.2006.12.007

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abstract = "Cancer stem cells (CSCs) are thought to be critical for initiation and propagation of many types of cancer. Because these cells are resistant to conventional therapies, they have been very difficult to eliminate. A study in this issue of Cancer Cell suggests that brain tumor CSCs live in a {"}vascular niche{"} that promotes their long-term growth and self-renewal. Disrupting this niche impairs CSC self-renewal and thereby significantly inhibits the growth of tumors. Targeting the unique microenvironment of CSCs may be the key to effective cancer therapy.",

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AB - Cancer stem cells (CSCs) are thought to be critical for initiation and propagation of many types of cancer. Because these cells are resistant to conventional therapies, they have been very difficult to eliminate. A study in this issue of Cancer Cell suggests that brain tumor CSCs live in a "vascular niche" that promotes their long-term growth and self-renewal. Disrupting this niche impairs CSC self-renewal and thereby significantly inhibits the growth of tumors. Targeting the unique microenvironment of CSCs may be the key to effective cancer therapy.

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Hit 'Em Where They Live: Targeting the Cancer Stem Cell Niche

Abstract

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