Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes

N. V. Maluchenko; D. S. Sultanov; E. Yu Kotova; M. P. Kirpichnikov; V. M. Studitsky; A. V. Feofanov

doi:10.1134/S1607672919060061

Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes

N. V. Maluchenko
, D. S. Sultanov
, E. Yu Kotova
, M. P. Kirpichnikov
, V. M. Studitsky
, A. V. Feofanov

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

Original language	English
Pages (from-to)	377-379
Number of pages	3
Journal	Doklady Biochemistry and Biophysics
Volume	489
Issue number	1
DOIs	https://doi.org/10.1134/S1607672919060061
State	Published - Nov 1 2019

Keywords

Animals
Histones/chemistry
Nucleosomes/metabolism
Poly (ADP-Ribose) Polymerase-1/metabolism
Xenopus laevis

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title = "Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes",

abstract = "PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.",

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doi = "10.1134/S1607672919060061",

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AU - Maluchenko, N. V.

AU - Sultanov, D. S.

AU - Kotova, E. Yu

AU - Kirpichnikov, M. P.

AU - Studitsky, V. M.

AU - Feofanov, A. V.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

AB - PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

KW - Animals

KW - Histones/chemistry

KW - Nucleosomes/metabolism

KW - Poly (ADP-Ribose) Polymerase-1/metabolism

KW - Xenopus laevis

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EP - 379

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

IS - 1

ER -

Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes

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