Histological study of normal and tumor-bearing liver treated with focused ultrasound

Lili Chen; Gail Ter Haar; David Robertson; John P.M. Bensted; Christopher R. Hill

doi:10.1016/S0301-5629(99)00028-9

Histological study of normal and tumor-bearing liver treated with focused ultrasound

Lili Chen, Gail Ter Haar, David Robertson, John P.M. Bensted, Christopher R. Hill

Royal Marsden Hospital

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The purpose of this investigation was to study the tissue damage (including blood vessels) on both normal and tumor-bearing experimental livers and the course of liver repair after focused ultrasound (FUS) treatment using histological evaluation. A series of experiments were carried out in vivo. Tissue was treated using arrays of ultrasound exposures with a frequency of 1.7 MHz, in situ spatially averaged focal intensity (I(SAL) in situ) of 212-266 W/cm² (corresponding to in situ spatial peak intensity of 382-479 W/cm²), 5-10 s exposure duration and 1.5-3.0 mm exposure separation. Tissue specimens were examined using both light and electron microscopy. The damage to the blood vessel walls was studied. The results showed the existence of indirect tissue damage in both normal and tumor tissue that is outside of the treatment volume, due to disruption of the major blood vessels supplying the adjacent area. Evidence for liver regeneration was found 2 months after FUS treatment.

Original language	English
Pages (from-to)	847-856
Number of pages	10
Journal	Ultrasound in Medicine and Biology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/S0301-5629(99)00028-9
State	Published - Jun 1999

Keywords

Animals
Fibrosarcoma/blood supply
Liver Neoplasms/blood supply
Liver Regeneration
Liver/blood supply
Microscopy, Electron
Rats
Time Factors
Ultrasonic Therapy/instrumentation
Ultrasonics/adverse effects

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10.1016/S0301-5629(99)00028-9

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title = "Histological study of normal and tumor-bearing liver treated with focused ultrasound",

abstract = "The purpose of this investigation was to study the tissue damage (including blood vessels) on both normal and tumor-bearing experimental livers and the course of liver repair after focused ultrasound (FUS) treatment using histological evaluation. A series of experiments were carried out in vivo. Tissue was treated using arrays of ultrasound exposures with a frequency of 1.7 MHz, in situ spatially averaged focal intensity (I(SAL) in situ) of 212-266 W/cm2 (corresponding to in situ spatial peak intensity of 382-479 W/cm2), 5-10 s exposure duration and 1.5-3.0 mm exposure separation. Tissue specimens were examined using both light and electron microscopy. The damage to the blood vessel walls was studied. The results showed the existence of indirect tissue damage in both normal and tumor tissue that is outside of the treatment volume, due to disruption of the major blood vessels supplying the adjacent area. Evidence for liver regeneration was found 2 months after FUS treatment.",

keywords = "Animals, Fibrosarcoma/blood supply, Liver Neoplasms/blood supply, Liver Regeneration, Liver/blood supply, Microscopy, Electron, Rats, Time Factors, Ultrasonic Therapy/instrumentation, Ultrasonics/adverse effects",

author = "Lili Chen and {Ter Haar}, Gail and David Robertson and Bensted, {John P.M.} and Hill, {Christopher R.}",

year = "1999",

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doi = "10.1016/S0301-5629(99)00028-9",

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AU - Chen, Lili

AU - Ter Haar, Gail

AU - Robertson, David

AU - Bensted, John P.M.

AU - Hill, Christopher R.

PY - 1999/6

Y1 - 1999/6

N2 - The purpose of this investigation was to study the tissue damage (including blood vessels) on both normal and tumor-bearing experimental livers and the course of liver repair after focused ultrasound (FUS) treatment using histological evaluation. A series of experiments were carried out in vivo. Tissue was treated using arrays of ultrasound exposures with a frequency of 1.7 MHz, in situ spatially averaged focal intensity (I(SAL) in situ) of 212-266 W/cm2 (corresponding to in situ spatial peak intensity of 382-479 W/cm2), 5-10 s exposure duration and 1.5-3.0 mm exposure separation. Tissue specimens were examined using both light and electron microscopy. The damage to the blood vessel walls was studied. The results showed the existence of indirect tissue damage in both normal and tumor tissue that is outside of the treatment volume, due to disruption of the major blood vessels supplying the adjacent area. Evidence for liver regeneration was found 2 months after FUS treatment.

AB - The purpose of this investigation was to study the tissue damage (including blood vessels) on both normal and tumor-bearing experimental livers and the course of liver repair after focused ultrasound (FUS) treatment using histological evaluation. A series of experiments were carried out in vivo. Tissue was treated using arrays of ultrasound exposures with a frequency of 1.7 MHz, in situ spatially averaged focal intensity (I(SAL) in situ) of 212-266 W/cm2 (corresponding to in situ spatial peak intensity of 382-479 W/cm2), 5-10 s exposure duration and 1.5-3.0 mm exposure separation. Tissue specimens were examined using both light and electron microscopy. The damage to the blood vessel walls was studied. The results showed the existence of indirect tissue damage in both normal and tumor tissue that is outside of the treatment volume, due to disruption of the major blood vessels supplying the adjacent area. Evidence for liver regeneration was found 2 months after FUS treatment.

KW - Animals

KW - Fibrosarcoma/blood supply

KW - Liver Neoplasms/blood supply

KW - Liver Regeneration

KW - Liver/blood supply

KW - Microscopy, Electron

KW - Rats

KW - Time Factors

KW - Ultrasonic Therapy/instrumentation

KW - Ultrasonics/adverse effects

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AN - SCOPUS:0033010062

SN - 0301-5629

VL - 25

SP - 847

EP - 856

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 5

ER -

Histological study of normal and tumor-bearing liver treated with focused ultrasound

Abstract

Keywords

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