TY - JOUR
T1 - Heterogeneity in head and neck cancer incidence among black populations from Africa, the Caribbean and the USA
T2 - Analysis of cancer registry data by the AC3
AU - Auguste, Aviane
AU - Gathere, Samuel
AU - Pinheiro, Paulo S.
AU - Adebamowo, Clement
AU - Akintola, Adeola
AU - Alleyne-Mike, Kellie
AU - Anderson, Simon G.
AU - Ashing, Kimlin
AU - Awittor, Fred Kwame
AU - Awuah, Baffour
AU - Bhakkan, Bernard
AU - Deloumeaux, Jacqueline
AU - du Plessis, Maira
AU - Ekanem, Ima Obong A.
AU - Ekanem, Uwemedimbuk
AU - Ezeome, Emmanuel
AU - Felix, Nkese
AU - Gachii, Andrew K.
AU - Gaete, Stanie
AU - Gibson, Tracey
AU - Hage, Robert
AU - Harrison, Sharon
AU - Igbinoba, Festus
AU - Iseh, Kufre
AU - Kiptanui, Evans
AU - Korir, Ann
AU - Lawson-Myers, Heather Dawn
AU - Llanos, Adana
AU - Luce, Daniele
AU - McNaughton, Dawn
AU - Odutola, Michael
AU - Omonisi, Abidemi
AU - Otu, Theresa
AU - Peruvien, Jessica
AU - Raheem, Nasiru
AU - Roach, Veronica
AU - Sobers, Natasha
AU - Uamburu, Nguundja
AU - Ragin, Camille
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/12
Y1 - 2021/12
N2 - Background: Africa and the Caribbean are projected to have greater increases in Head and neck cancer (HNC) burden in comparison to North America and Europe. The knowledge needed to reinforce prevention in these populations is limited. We compared for the first time, incidence rates of HNC in black populations from African, the Caribbean and USA. Methods: Annual age-standardized incidence rates (IR) and 95% confidence intervals (95%CI) per 100,000 were calculated for 2013–2015 using population-based cancer registry data for 14,911 HNC cases from the Caribbean (Barbados, Guadeloupe, Trinidad & Tobago, N = 443), Africa (Kenya, Nigeria, N = 772) and the United States (SEER, Florida, N = 13,696). We compared rates by sub-sites and sex among countries using data from registries with high quality and completeness. Results: In 2013–2015, compared to other countries, HNC incidence was highest among SEER states (IR: 18.2, 95%CI = 17.6–18.8) among men, and highest in Kenya (IR: 7.5, 95%CI = 6.3–8.7) among women. Nasopharyngeal cancer IR was higher in Kenya for men (IR: 3.1, 95%CI = 2.5–3.7) and women (IR: 1.5, 95%CI = 1.0–1.9). Female oral cavity cancer was also notably higher in Kenya (IR = 3.9, 95%CI = 3.0–4.9). Blacks from SEER states had higher incidence of laryngeal cancer (IR: 5.5, 95%CI = 5.2–5.8) compared to other countries and even Florida blacks (IR: 4.4, 95%CI = 3.9–5.0). Conclusion: We found heterogeneity in IRs for HNC among these diverse black populations; notably, Kenya which had distinctively higher incidence of nasopharyngeal and female oral cavity cancer. Targeted etiological investigations are warranted considering the low consumption of tobacco and alcohol among Kenyan women. Overall, our findings suggest that behavioral and environmental factors are more important determinants of HNC than race.
AB - Background: Africa and the Caribbean are projected to have greater increases in Head and neck cancer (HNC) burden in comparison to North America and Europe. The knowledge needed to reinforce prevention in these populations is limited. We compared for the first time, incidence rates of HNC in black populations from African, the Caribbean and USA. Methods: Annual age-standardized incidence rates (IR) and 95% confidence intervals (95%CI) per 100,000 were calculated for 2013–2015 using population-based cancer registry data for 14,911 HNC cases from the Caribbean (Barbados, Guadeloupe, Trinidad & Tobago, N = 443), Africa (Kenya, Nigeria, N = 772) and the United States (SEER, Florida, N = 13,696). We compared rates by sub-sites and sex among countries using data from registries with high quality and completeness. Results: In 2013–2015, compared to other countries, HNC incidence was highest among SEER states (IR: 18.2, 95%CI = 17.6–18.8) among men, and highest in Kenya (IR: 7.5, 95%CI = 6.3–8.7) among women. Nasopharyngeal cancer IR was higher in Kenya for men (IR: 3.1, 95%CI = 2.5–3.7) and women (IR: 1.5, 95%CI = 1.0–1.9). Female oral cavity cancer was also notably higher in Kenya (IR = 3.9, 95%CI = 3.0–4.9). Blacks from SEER states had higher incidence of laryngeal cancer (IR: 5.5, 95%CI = 5.2–5.8) compared to other countries and even Florida blacks (IR: 4.4, 95%CI = 3.9–5.0). Conclusion: We found heterogeneity in IRs for HNC among these diverse black populations; notably, Kenya which had distinctively higher incidence of nasopharyngeal and female oral cavity cancer. Targeted etiological investigations are warranted considering the low consumption of tobacco and alcohol among Kenyan women. Overall, our findings suggest that behavioral and environmental factors are more important determinants of HNC than race.
KW - Africa
KW - Alcohol drinking
KW - Blacks
KW - Caribbean
KW - HPV
KW - Head and neck cancer
KW - Incidence
KW - Population-based cancer registry
KW - Tobacco smoking
KW - USA
UR - http://www.scopus.com/inward/record.url?scp=85120674245&partnerID=8YFLogxK
U2 - 10.1016/j.canep.2021.102053
DO - 10.1016/j.canep.2021.102053
M3 - Article
C2 - 34743058
SN - 1877-7821
VL - 75
SP - 102053
JO - Cancer Epidemiology
JF - Cancer Epidemiology
M1 - 102053
ER -