TY - JOUR
T1 - Hepatocellular carcinoma in older adults
T2 - A comprehensive review by Young International Society of Geriatric Oncology
AU - Arora, Sukeshi P.
AU - Liposits, Gabor
AU - Caird, Susan
AU - Dunne, Richard F.
AU - Moffat, Gordon Taylor
AU - Okonji, David
AU - Rodriguenz, Maria Grazia
AU - Dua, Divyanshu
AU - Dotan, Efrat
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2020/5
Y1 - 2020/5
N2 - Given the prevalence and the rising incidence of hepatocellular carcinoma (HCC) in older adults worldwide, there is an urgent need to improve our understanding of the implications of treatment modalities in this population. The care of older patients with HCC is challenging due to the lack of evidence-based recommendations in this population. The current treatment approach for older patients relies on extrapolation of data from clinical trials conducted mostly in younger patients or fit older adults. Further, in the last few years, the arsenal of systemic treatments has increased with currently seven FDA-approved therapies available for patients with advanced HCC. Therefore, understanding how to apply current data to this unique and diverse patient population is necessary. This review will aim to shed light on the approach to older adults with HCC through an assessment of available data in the literature.
AB - Given the prevalence and the rising incidence of hepatocellular carcinoma (HCC) in older adults worldwide, there is an urgent need to improve our understanding of the implications of treatment modalities in this population. The care of older patients with HCC is challenging due to the lack of evidence-based recommendations in this population. The current treatment approach for older patients relies on extrapolation of data from clinical trials conducted mostly in younger patients or fit older adults. Further, in the last few years, the arsenal of systemic treatments has increased with currently seven FDA-approved therapies available for patients with advanced HCC. Therefore, understanding how to apply current data to this unique and diverse patient population is necessary. This review will aim to shed light on the approach to older adults with HCC through an assessment of available data in the literature.
KW - Aged
KW - Carcinoma, Hepatocellular/epidemiology
KW - Humans
KW - Liver Neoplasms/epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85075508865&partnerID=8YFLogxK
U2 - 10.1016/j.jgo.2019.10.007
DO - 10.1016/j.jgo.2019.10.007
M3 - Review article
C2 - 31704038
SN - 1879-4068
VL - 11
SP - 557
EP - 565
JO - Journal of Geriatric Oncology
JF - Journal of Geriatric Oncology
IS - 4
ER -