Abstract
Group I p21-activated kinases are a highly conserved three-member family of serine/threonine kinases that act as key effectors for the small GTPases Cdc42 and Rac. In man, these enzymes have been implicated in a wide range of biological processes and are beginning to draw the attention of the pharmaceutical industry as potential therapeutic targets in cancer and in inflammatory processes. In this review, we summarize basic properties of group I Paks and discuss recently uncovered roles for these kinases in immune function and in viral infection.
| Original language | English |
|---|---|
| Pages (from-to) | 13-16 |
| Number of pages | 4 |
| Journal | International Journal of Biochemistry and Cell Biology |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2010 |
Keywords
- Cell signalling
- Immune function
- P21-activated kinases
- Rho GTPases
- Viral pathogenesis
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