TY - JOUR
T1 - Group I p21-activated kinases
T2 - Emerging roles in immune function and viral pathogenesis
AU - Pacheco, Almudena
AU - Chernoff, Jonathan
PY - 2010/1
Y1 - 2010/1
N2 - Group I p21-activated kinases are a highly conserved three-member family of serine/threonine kinases that act as key effectors for the small GTPases Cdc42 and Rac. In man, these enzymes have been implicated in a wide range of biological processes and are beginning to draw the attention of the pharmaceutical industry as potential therapeutic targets in cancer and in inflammatory processes. In this review, we summarize basic properties of group I Paks and discuss recently uncovered roles for these kinases in immune function and in viral infection.
AB - Group I p21-activated kinases are a highly conserved three-member family of serine/threonine kinases that act as key effectors for the small GTPases Cdc42 and Rac. In man, these enzymes have been implicated in a wide range of biological processes and are beginning to draw the attention of the pharmaceutical industry as potential therapeutic targets in cancer and in inflammatory processes. In this review, we summarize basic properties of group I Paks and discuss recently uncovered roles for these kinases in immune function and in viral infection.
KW - Cell signalling
KW - Immune function
KW - P21-activated kinases
KW - Rho GTPases
KW - Viral pathogenesis
UR - http://www.scopus.com/inward/record.url?scp=70549106855&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000273912200003&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.biocel.2009.09.006
DO - 10.1016/j.biocel.2009.09.006
M3 - Short survey
C2 - 19747561
SN - 1357-2725
VL - 42
SP - 13
EP - 16
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 1
ER -