GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma

Ting Liu, Xue Feng Kan, Charlie Ma, Lili Chen, Tian Tian Cheng, Zhen Wei Zou, Yong Li, Feng Jun Cao, Wen Jie Zhang, Jing Yao, Pin Dong Li

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Glutathione peroxidase 2 has important role of tumor progression in lots of carcinomas, yet little is known about the prognosis of glutathione peroxidase 2 in hepatocellular carcinoma. Glutathione peroxidase 2 expression was assessed by immunohistochemistry in hepatocellular carcinoma tissues. The association between glutathione peroxidase 2 expression with clinicopathological/prognostic value was examined. Glutathione peroxidase 2 overexpression was correlated with alpha-fetoprotein level, larger tumor, BCLC stage, and tumor recurrence. Kaplan-Meier analysis showed that glutathione peroxidase 2 was an independent predictor for overall survival and time to recurrence. glutathione peroxidase 2 overexpression was correlated with poor prognosis in patient subgroups stratified by tumor size, differentiation, tumor-node-metastasis, and BCLC stage. Moreover, stratified analysis showed that tumor-node-metastasis stage-I patients with high glutathione peroxidase 2 expression had poor prognosis than those with low glutathione peroxidase 2 expression. Additionally, combination of glutathione peroxidase 2 and serum alpha-fetoprotein was correlated with prognosis in hepatocellular carcinoma. In conclusion, glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients.

Original languageEnglish
Pages (from-to)1010428317700410
JournalTumor Biology
Volume39
Issue number6
DOIs
StatePublished - Jan 1 2017

Keywords

  • Glutathione peroxidase 2
  • Hepatocellular carcinoma
  • Prognosis

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