Genomic fold assignment and rational modeling of proteins of biological interest

J. Michael Sauder, Roland L. Dunbrack

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.

Original languageEnglish
Title of host publicationProceedings of the 8th International Conference on Intelligent Systems for Molecular Biology, ISMB 2000
PublisherAAAI Press
ISBN (Electronic)1577351150, 9781577351153
StatePublished - 2000
Event8th International Conference on Intelligent Systems for Molecular Biology, ISMB 2000 - San Diego, United States
Duration: Aug 19 2000Aug 23 2000

Publication series

NameProceedings of the 8th International Conference on Intelligent Systems for Molecular Biology, ISMB 2000

Conference

Conference8th International Conference on Intelligent Systems for Molecular Biology, ISMB 2000
Country/TerritoryUnited States
CitySan Diego
Period08/19/0008/23/00

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