Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Christopher A. Haiman; Gary K. Chen; William J. Blot; Sara S. Strom; Sonja I. Berndt; Rick A. Kittles; Benjamin A. Rybicki; William B. Isaacs; Sue A. Ingles; Janet L. Stanford; W. Ryan Diver; John S. Witte; Ann W. Hsing; Barbara Nemesure; Timothy R. Rebbeck; Kathleen A. Cooney; Jianfeng Xu; Adam S. Kibel; Jennifer J. Hu; Esther M. John; Serigne M. Gueye; Stephen Watya; Lisa B. Signorello; Richard B. Hayes; Zhaoming Wang; Edward Yeboah; Yao Tettey; Qiuyin Cai; Suzanne Kolb; Elaine A. Ostrander; Charnita Zeigler-Johnson; Yuko Yamamura; Christine Neslund-Dudas; Jennifer Haslag-Minoff; William Wu; Venetta Thomas; Glenn O. Allen; Adam Murphy; Bao Li Chang; S. Lilly Zheng; M. Cristina Leske; Suh Yuh Wu; Anna M. Ray; Anselm J.M. Hennis; Michael J. Thun; John Carpten; Graham Casey; Erin N. Carter; Edder R. Duarte; Lucy Y. Xia; Xin Sheng; Peggy Wan; Loreall C. Pooler; Iona Cheng; Kristine R. Monroe; Fredrick Schumacher; Loic Le Marchand; Laurence N. Kolonel; Stephen J. Chanock; David Van Den Berg; Daniel O. Stram; Brian E. Henderson

doi:10.1038/ng.839

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Christopher A. Haiman, Gary K. Chen, William J. Blot, Sara S. Strom, Sonja I. Berndt, Rick A. Kittles, Benjamin A. Rybicki, William B. Isaacs, Sue A. Ingles, Janet L. Stanford, W. Ryan Diver, John S. Witte, Ann W. Hsing, Barbara Nemesure, Timothy R. Rebbeck, Kathleen A. Cooney, Jianfeng Xu, Adam S. Kibel, Jennifer J. Hu, Esther M. JohnSerigne M. Gueye, Stephen Watya, Lisa B. Signorello, Richard B. Hayes, Zhaoming Wang, Edward Yeboah, Yao Tettey, Qiuyin Cai, Suzanne Kolb, Elaine A. Ostrander, Charnita Zeigler-Johnson, Yuko Yamamura, Christine Neslund-Dudas, Jennifer Haslag-Minoff, William Wu, Venetta Thomas, Glenn O. Allen, Adam Murphy, Bao Li Chang, S. Lilly Zheng, M. Cristina Leske, Suh Yuh Wu, Anna M. Ray, Anselm J.M. Hennis, Michael J. Thun, John Carpten, Graham Casey, Erin N. Carter, Edder R. Duarte, Lucy Y. Xia, Xin Sheng, Peggy Wan, Loreall C. Pooler, Iona Cheng, Kristine R. Monroe, Fredrick Schumacher, Loic Le Marchand, Laurence N. Kolonel, Stephen J. Chanock, David Van Den Berg, Daniel O. Stram, Brian E. Henderson

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Abstract

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10-13). The frequency of the risk allele is ̃5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

Original language	English
Pages (from-to)	570-573
Number of pages	4
Journal	Nature Genetics
Volume	43
Issue number	6
DOIs	https://doi.org/10.1038/ng.839
State	Published - May 2011

Keywords

Black or African American/genetics
Chromosomes, Human, Pair 17
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Polymorphism, Single Nucleotide
Prostatic Neoplasms/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng.839

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Haiman, C. A., Chen, G. K., Blot, W. J., Strom, S. S., Berndt, S. I., Kittles, R. A., Rybicki, B. A., Isaacs, W. B., Ingles, S. A., Stanford, J. L., Diver, W. R., Witte, J. S., Hsing, A. W., Nemesure, B., Rebbeck, T. R., Cooney, K. A., Xu, J., Kibel, A. S., Hu, J. J., ... Henderson, B. E. (2011). Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nature Genetics, 43(6), 570-573. https://doi.org/10.1038/ng.839

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title = "Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21",

abstract = "In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10-13). The frequency of the risk allele is{\~ }5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.",

keywords = "Black or African American/genetics, Chromosomes, Human, Pair 17, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms/genetics",

author = "Haiman, {Christopher A.} and Chen, {Gary K.} and Blot, {William J.} and Strom, {Sara S.} and Berndt, {Sonja I.} and Kittles, {Rick A.} and Rybicki, {Benjamin A.} and Isaacs, {William B.} and Ingles, {Sue A.} and Stanford, {Janet L.} and Diver, {W. Ryan} and Witte, {John S.} and Hsing, {Ann W.} and Barbara Nemesure and Rebbeck, {Timothy R.} and Cooney, {Kathleen A.} and Jianfeng Xu and Kibel, {Adam S.} and Hu, {Jennifer J.} and John, {Esther M.} and Gueye, {Serigne M.} and Stephen Watya and Signorello, {Lisa B.} and Hayes, {Richard B.} and Zhaoming Wang and Edward Yeboah and Yao Tettey and Qiuyin Cai and Suzanne Kolb and Ostrander, {Elaine A.} and Charnita Zeigler-Johnson and Yuko Yamamura and Christine Neslund-Dudas and Jennifer Haslag-Minoff and William Wu and Venetta Thomas and Allen, {Glenn O.} and Adam Murphy and Chang, {Bao Li} and Zheng, {S. Lilly} and Leske, {M. Cristina} and Wu, {Suh Yuh} and Ray, {Anna M.} and Hennis, {Anselm J.M.} and Thun, {Michael J.} and John Carpten and Graham Casey and Carter, {Erin N.} and Duarte, {Edder R.} and Xia, {Lucy Y.} and Xin Sheng and Peggy Wan and Pooler, {Loreall C.} and Iona Cheng and Monroe, {Kristine R.} and Fredrick Schumacher and {Le Marchand}, Loic and Kolonel, {Laurence N.} and Chanock, {Stephen J.} and Berg, {David Van Den} and Stram, {Daniel O.} and Henderson, {Brian E.}",

year = "2011",

month = may,

doi = "10.1038/ng.839",

language = "English",

volume = "43",

pages = "570--573",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "6",

}

Haiman, CA, Chen, GK, Blot, WJ, Strom, SS, Berndt, SI, Kittles, RA, Rybicki, BA, Isaacs, WB, Ingles, SA, Stanford, JL, Diver, WR, Witte, JS, Hsing, AW, Nemesure, B, Rebbeck, TR, Cooney, KA, Xu, J, Kibel, AS, Hu, JJ, John, EM, Gueye, SM, Watya, S, Signorello, LB, Hayes, RB, Wang, Z, Yeboah, E, Tettey, Y, Cai, Q, Kolb, S, Ostrander, EA, Zeigler-Johnson, C, Yamamura, Y, Neslund-Dudas, C, Haslag-Minoff, J, Wu, W, Thomas, V, Allen, GO, Murphy, A, Chang, BL, Zheng, SL, Leske, MC, Wu, SY, Ray, AM, Hennis, AJM, Thun, MJ, Carpten, J, Casey, G, Carter, EN, Duarte, ER, Xia, LY, Sheng, X, Wan, P, Pooler, LC, Cheng, I, Monroe, KR, Schumacher, F, Le Marchand, L, Kolonel, LN, Chanock, SJ, Berg, DVD, Stram, DO & Henderson, BE 2011, 'Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21', Nature Genetics, vol. 43, no. 6, pp. 570-573. https://doi.org/10.1038/ng.839

TY - JOUR

T1 - Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

AU - Haiman, Christopher A.

AU - Chen, Gary K.

AU - Blot, William J.

AU - Strom, Sara S.

AU - Berndt, Sonja I.

AU - Kittles, Rick A.

AU - Rybicki, Benjamin A.

AU - Isaacs, William B.

AU - Ingles, Sue A.

AU - Stanford, Janet L.

AU - Diver, W. Ryan

AU - Witte, John S.

AU - Hsing, Ann W.

AU - Nemesure, Barbara

AU - Rebbeck, Timothy R.

AU - Cooney, Kathleen A.

AU - Xu, Jianfeng

AU - Kibel, Adam S.

AU - Hu, Jennifer J.

AU - John, Esther M.

AU - Gueye, Serigne M.

AU - Watya, Stephen

AU - Signorello, Lisa B.

AU - Hayes, Richard B.

AU - Wang, Zhaoming

AU - Yeboah, Edward

AU - Tettey, Yao

AU - Cai, Qiuyin

AU - Kolb, Suzanne

AU - Ostrander, Elaine A.

AU - Zeigler-Johnson, Charnita

AU - Yamamura, Yuko

AU - Neslund-Dudas, Christine

AU - Haslag-Minoff, Jennifer

AU - Wu, William

AU - Thomas, Venetta

AU - Allen, Glenn O.

AU - Murphy, Adam

AU - Chang, Bao Li

AU - Zheng, S. Lilly

AU - Leske, M. Cristina

AU - Wu, Suh Yuh

AU - Ray, Anna M.

AU - Hennis, Anselm J.M.

AU - Thun, Michael J.

AU - Carpten, John

AU - Casey, Graham

AU - Carter, Erin N.

AU - Duarte, Edder R.

AU - Xia, Lucy Y.

AU - Sheng, Xin

AU - Wan, Peggy

AU - Pooler, Loreall C.

AU - Cheng, Iona

AU - Monroe, Kristine R.

AU - Schumacher, Fredrick

AU - Le Marchand, Loic

AU - Kolonel, Laurence N.

AU - Chanock, Stephen J.

AU - Berg, David Van Den

AU - Stram, Daniel O.

AU - Henderson, Brian E.

PY - 2011/5

Y1 - 2011/5

N2 - In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10-13). The frequency of the risk allele is ̃5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

AB - In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10-13). The frequency of the risk allele is ̃5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

KW - Black or African American/genetics

KW - Chromosomes, Human, Pair 17

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms/genetics

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U2 - 10.1038/ng.839

DO - 10.1038/ng.839

M3 - Article

C2 - 21602798

SN - 1061-4036

VL - 43

SP - 570

EP - 573

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Abstract

Keywords

UN SDGs

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