Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

Laufey Amundadottir; Peter Kraft; Rachael Z. Stolzenberg-Solomon; Charles S. Fuchs; Gloria M. Petersen; Alan A. Arslan; H. Bas Bueno-De-Mesquita; Myron Gross; Kathy Helzlsouer; Eric J. Jacobs; Andrea LaCroix; Wei Zheng; Demetrius Albanes; William Bamlet; Christine D. Berg; Franco Berrino; Sheila Bingham; Julie E. Buring; Paige M. Bracci; Federico Canzian; Françoise Clavel-Chapelon; Sandra Clipp; Michelle Cotterchio; Mariza De Andrade; Eric J. Duell; John W. Fox; Steven Gallinger; J. Michael Gaziano; Edward L. Giovannucci; Michael Goggins; Carlos A. González; Göran Hallmans; Susan E. Hankinson; Manal Hassan; Elizabeth A. Holly; David J. Hunter; Amy Hutchinson; Rebecca Jackson; Kevin B. Jacobs; Mazda Jenab; Rudolf Kaaks; Alison P. Klein; Charles Kooperberg; Robert C. Kurtz; Donghui Li; Shannon M. Lynch; Margaret Mandelson; Robert R. McWilliams; Julie B. Mendelsohn; Dominique S. Michaud; Sara H. Olson; Kim Overvad; Alpa V. Patel; Petra H.M. Peeters; Aleksandar Rajkovic; Elio Riboli; Harvey A. Risch; Xiao Ou Shu; Gilles Thomas; Geoffrey S. Tobias; Dimitrios Trichopoulos; Stephen K. Van Den Eeden; Jarmo Virtamo; Jean Wactawski-Wende; Brian M. Wolpin; Herbert Yu; Kai Yu; Anne Zeleniuch-Jacquotte; Stephen J. Chanock; Patricia Hartge; Robert N. Hoover

doi:10.1038/ng.429

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

Laufey Amundadottir
, Peter Kraft
, Rachael Z. Stolzenberg-Solomon
, Charles S. Fuchs
, Gloria M. Petersen
, Alan A. Arslan
, H. Bas Bueno-De-Mesquita
, Myron Gross
, Kathy Helzlsouer
, Eric J. Jacobs
, Andrea LaCroix
, Wei Zheng
, Demetrius Albanes
, William Bamlet
, Christine D. Berg
, Franco Berrino
, Sheila Bingham
, Julie E. Buring
, Paige M. Bracci
, Federico Canzian

Françoise Clavel-Chapelon, Sandra Clipp, Michelle Cotterchio, Mariza De Andrade, Eric J. Duell, John W. Fox, Steven Gallinger, J. Michael Gaziano, Edward L. Giovannucci, Michael Goggins, Carlos A. González, Göran Hallmans, Susan E. Hankinson, Manal Hassan, Elizabeth A. Holly, David J. Hunter, Amy Hutchinson, Rebecca Jackson, Kevin B. Jacobs, Mazda Jenab, Rudolf Kaaks, Alison P. Klein, Charles Kooperberg, Robert C. Kurtz, Donghui Li, Shannon M. Lynch, Margaret Mandelson, Robert R. McWilliams, Julie B. Mendelsohn, Dominique S. Michaud, Sara H. Olson, Kim Overvad, Alpa V. Patel, Petra H.M. Peeters, Aleksandar Rajkovic, Elio Riboli, Harvey A. Risch, Xiao Ou Shu, Gilles Thomas, Geoffrey S. Tobias, Dimitrios Trichopoulos, Stephen K. Van Den Eeden, Jarmo Virtamo, Jean Wactawski-Wende, Brian M. Wolpin, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Stephen J. Chanock, Patricia Hartge, Robert N. Hoover

National Institutes of Health
Harvard University
Dana-Farber Cancer Institute
Brigham and Women's Hospital
Mayo Clinic
New York University
National Institute of Public Health and the Environment
Utrecht University
University of Minnesota Twin Cities
Mercy Medical Center Baltimore
American Cancer Society
Fred Hutchinson Cancer Research Center
Vanderbilt University
Fondazione IRCCS Istituto Nazionale dei Tumori
University of Cambridge
University of California at San Francisco
German Cancer Research Center
Institut national de la santé et de la recherche médicale
Johns Hopkins University
University of Toronto
International Agency for Research on Cancer
Michigan State University
VA Medical Center
Institute Catala Oncologia
Umeå University
University of Texas MD Anderson Cancer Center
SAIC
Ohio State University
BioInformed LLC
Memorial Sloan-Kettering Cancer Center
Group Health Cooperative
Imperial College London
Aalborg University
Baylor College of Medicine
Yale University
National and Kapodistrian University of Athens
Kaiser Permanente
National Institute for Health and Welfare
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

604 Scopus citations

Abstract

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10^-8; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

Original language	English
Pages (from-to)	986-990
Number of pages	5
Journal	Nature Genetics
Volume	41
Issue number	9
DOIs	https://doi.org/10.1038/ng.429
State	Published - Aug 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ABO Blood-Group System/genetics
Alleles
Case-Control Studies
Chromosomes, Human, Pair 9
Cohort Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Introns
Linkage Disequilibrium
Logistic Models
Male
Odds Ratio
Pancreatic Neoplasms/genetics
Polymorphism, Single Nucleotide
Prospective Studies
Risk Factors
United States

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10.1038/ng.429

Cite this

Amundadottir, L., Kraft, P., Stolzenberg-Solomon, R. Z., Fuchs, C. S., Petersen, G. M., Arslan, A. A., Bueno-De-Mesquita, H. B., Gross, M., Helzlsouer, K., Jacobs, E. J., LaCroix, A., Zheng, W., Albanes, D., Bamlet, W., Berg, C. D., Berrino, F., Bingham, S., Buring, J. E., Bracci, P. M., ... Hoover, R. N. (2009). Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nature Genetics, 41(9), 986-990. https://doi.org/10.1038/ng.429

@article{e2053ec78a594c8fa734639934c0a460,

title = "Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer",

abstract = "We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10-8; multiplicative per-allele odds ratio 1.20; 95\% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.",

keywords = "ABO Blood-Group System/genetics, Alleles, Case-Control Studies, Chromosomes, Human, Pair 9, Cohort Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Haplotypes, Humans, Introns, Linkage Disequilibrium, Logistic Models, Male, Odds Ratio, Pancreatic Neoplasms/genetics, Polymorphism, Single Nucleotide, Prospective Studies, Risk Factors, United States",

author = "Laufey Amundadottir and Peter Kraft and Stolzenberg-Solomon, \{Rachael Z.\} and Fuchs, \{Charles S.\} and Petersen, \{Gloria M.\} and Arslan, \{Alan A.\} and Bueno-De-Mesquita, \{H. Bas\} and Myron Gross and Kathy Helzlsouer and Jacobs, \{Eric J.\} and Andrea LaCroix and Wei Zheng and Demetrius Albanes and William Bamlet and Berg, \{Christine D.\} and Franco Berrino and Sheila Bingham and Buring, \{Julie E.\} and Bracci, \{Paige M.\} and Federico Canzian and Fran{\c c}oise Clavel-Chapelon and Sandra Clipp and Michelle Cotterchio and \{De Andrade\}, Mariza and Duell, \{Eric J.\} and Fox, \{John W.\} and Steven Gallinger and Gaziano, \{J. Michael\} and Giovannucci, \{Edward L.\} and Michael Goggins and Gonz{\'a}lez, \{Carlos A.\} and G{\"o}ran Hallmans and Hankinson, \{Susan E.\} and Manal Hassan and Holly, \{Elizabeth A.\} and Hunter, \{David J.\} and Amy Hutchinson and Rebecca Jackson and Jacobs, \{Kevin B.\} and Mazda Jenab and Rudolf Kaaks and Klein, \{Alison P.\} and Charles Kooperberg and Kurtz, \{Robert C.\} and Donghui Li and Lynch, \{Shannon M.\} and Margaret Mandelson and McWilliams, \{Robert R.\} and Mendelsohn, \{Julie B.\} and Michaud, \{Dominique S.\} and Olson, \{Sara H.\} and Kim Overvad and Patel, \{Alpa V.\} and Peeters, \{Petra H.M.\} and Aleksandar Rajkovic and Elio Riboli and Risch, \{Harvey A.\} and Shu, \{Xiao Ou\} and Gilles Thomas and Tobias, \{Geoffrey S.\} and Dimitrios Trichopoulos and \{Van Den Eeden\}, \{Stephen K.\} and Jarmo Virtamo and Jean Wactawski-Wende and Wolpin, \{Brian M.\} and Herbert Yu and Kai Yu and Anne Zeleniuch-Jacquotte and Chanock, \{Stephen J.\} and Patricia Hartge and Hoover, \{Robert N.\}",

year = "2009",

month = aug,

doi = "10.1038/ng.429",

language = "English",

volume = "41",

pages = "986--990",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "9",

}

Amundadottir, L, Kraft, P, Stolzenberg-Solomon, RZ, Fuchs, CS, Petersen, GM, Arslan, AA, Bueno-De-Mesquita, HB, Gross, M, Helzlsouer, K, Jacobs, EJ, LaCroix, A, Zheng, W, Albanes, D, Bamlet, W, Berg, CD, Berrino, F, Bingham, S, Buring, JE, Bracci, PM, Canzian, F, Clavel-Chapelon, F, Clipp, S, Cotterchio, M, De Andrade, M, Duell, EJ, Fox, JW, Gallinger, S, Gaziano, JM, Giovannucci, EL, Goggins, M, González, CA, Hallmans, G, Hankinson, SE, Hassan, M, Holly, EA, Hunter, DJ, Hutchinson, A, Jackson, R, Jacobs, KB, Jenab, M, Kaaks, R, Klein, AP, Kooperberg, C, Kurtz, RC, Li, D, Lynch, SM, Mandelson, M, McWilliams, RR, Mendelsohn, JB, Michaud, DS, Olson, SH, Overvad, K, Patel, AV, Peeters, PHM, Rajkovic, A, Riboli, E, Risch, HA, Shu, XO, Thomas, G, Tobias, GS, Trichopoulos, D, Van Den Eeden, SK, Virtamo, J, Wactawski-Wende, J, Wolpin, BM, Yu, H, Yu, K, Zeleniuch-Jacquotte, A, Chanock, SJ, Hartge, P & Hoover, RN 2009, 'Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer', Nature Genetics, vol. 41, no. 9, pp. 986-990. https://doi.org/10.1038/ng.429

TY - JOUR

T1 - Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

AU - Amundadottir, Laufey

AU - Kraft, Peter

AU - Stolzenberg-Solomon, Rachael Z.

AU - Fuchs, Charles S.

AU - Petersen, Gloria M.

AU - Arslan, Alan A.

AU - Bueno-De-Mesquita, H. Bas

AU - Gross, Myron

AU - Helzlsouer, Kathy

AU - Jacobs, Eric J.

AU - LaCroix, Andrea

AU - Zheng, Wei

AU - Albanes, Demetrius

AU - Bamlet, William

AU - Berg, Christine D.

AU - Berrino, Franco

AU - Bingham, Sheila

AU - Buring, Julie E.

AU - Bracci, Paige M.

AU - Canzian, Federico

AU - Clavel-Chapelon, Françoise

AU - Clipp, Sandra

AU - Cotterchio, Michelle

AU - De Andrade, Mariza

AU - Duell, Eric J.

AU - Fox, John W.

AU - Gallinger, Steven

AU - Gaziano, J. Michael

AU - Giovannucci, Edward L.

AU - Goggins, Michael

AU - González, Carlos A.

AU - Hallmans, Göran

AU - Hankinson, Susan E.

AU - Hassan, Manal

AU - Holly, Elizabeth A.

AU - Hunter, David J.

AU - Hutchinson, Amy

AU - Jackson, Rebecca

AU - Jacobs, Kevin B.

AU - Jenab, Mazda

AU - Kaaks, Rudolf

AU - Klein, Alison P.

AU - Kooperberg, Charles

AU - Kurtz, Robert C.

AU - Li, Donghui

AU - Lynch, Shannon M.

AU - Mandelson, Margaret

AU - McWilliams, Robert R.

AU - Mendelsohn, Julie B.

AU - Michaud, Dominique S.

AU - Olson, Sara H.

AU - Overvad, Kim

AU - Patel, Alpa V.

AU - Peeters, Petra H.M.

AU - Rajkovic, Aleksandar

AU - Riboli, Elio

AU - Risch, Harvey A.

AU - Shu, Xiao Ou

AU - Thomas, Gilles

AU - Tobias, Geoffrey S.

AU - Trichopoulos, Dimitrios

AU - Van Den Eeden, Stephen K.

AU - Virtamo, Jarmo

AU - Wactawski-Wende, Jean

AU - Wolpin, Brian M.

AU - Yu, Herbert

AU - Yu, Kai

AU - Zeleniuch-Jacquotte, Anne

AU - Chanock, Stephen J.

AU - Hartge, Patricia

AU - Hoover, Robert N.

PY - 2009/8

Y1 - 2009/8

N2 - We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10-8; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

AB - We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 × 10-8; multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

KW - ABO Blood-Group System/genetics

KW - Alleles

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 9

KW - Cohort Studies

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Introns

KW - Linkage Disequilibrium

KW - Logistic Models

KW - Male

KW - Odds Ratio

KW - Pancreatic Neoplasms/genetics

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Risk Factors

KW - United States

UR - https://www.scopus.com/pages/publications/69349097813

U2 - 10.1038/ng.429

DO - 10.1038/ng.429

M3 - Article

C2 - 19648918

AN - SCOPUS:69349097813

SN - 1061-4036

VL - 41

SP - 986

EP - 990

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer

Abstract

UN SDGs

Keywords

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